Self-micro emulsion solft capsule of dihydropyridine type calcium ion agonist, and its prepn. method

A technology of calcium ion antagonists and dihydropyridines, which is applied in the field of self-microemulsifying soft capsules of dihydropyridine calcium ion antagonists and its preparation, can solve the problems of poor water solubility, low dissolution rate, and low bioavailability, etc. Achieve high dissolution rate, increase dissolution rate, and good water solubility
CN1559407AInactive Publication Date: 2005-01-05SHENYANG PHARMA UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHENYANG PHARMA UNIVERSITY
Publication Date
2005-01-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

A self-microemulsified softcapsule of nimodipine or nitrendipine is prepared from nimodipine or nitrendipine, coemulsifier, self emulsifier, oil and antioxidizing agent through proportionally mixing nimodipine or nitrendipine, coemulsifier and self emulsifier, constant-temp oscillating, adding oil and antioxidizing agent, stirring, cooling, and shaping.
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Description

Technical field:

[0001] The invention relates to the technical field of medicine, in particular to a self-microemulsifying soft capsule of nitrendipine or a dihydropyridine calcium ion antagonist of nimodipine and a preparation method thereof. Background technique:

[0002] Nitrendipine (nitrendipine) is a dihydropyridine calcium antagonist, which has strong selectivity to vascular smooth muscle, but has a weak effect on cardiac muscle, so it can cause blood vessels around the body, including coronary arteries and renal arterioles, to expand , produces a hypotensive effect, but has little effect on normal blood pressure. It is mainly used to treat various types of hypertension, and the antihypertensive effect is significant and long-lasting, especially suitable for elderly hypertensive patients, and can improve the blood supply and myocardial function of the heart, kidney, and brain while reducing blood pressure.

[0003] Nitrendipine has low oral bioavailability, t 1 / 2 fo...

Claims

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