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Plant hard hollow capsule and its preparng method

A hollow capsule and plant technology, which is applied in the field of plant hard hollow capsules, the preparation of plant hard hollow capsules, and the carboxymethyl konjac glucomannan-soybean protein isolate complex, can solve the problem of easy pollution, unfavorable storage, unsuitable for easy storage, etc. Hygroscopic drugs and other problems, to achieve the effect of not easy to contaminate, good drug stability, and meet the requirements

Inactive Publication Date: 2005-01-12
湖北工学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Overcome the disadvantages of gelatin hard hollow capsules that are not conducive to storage, easy to pollute, unsuitable for hygroscopic drugs and unable to meet the requirements of vegetarians, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Raw material % by weight

[0044] Carboxymethyl Konjac Glucomannan 42.6%

[0045] Soy Protein Isolate 28.4%

[0046] Carrageenan 17.7%

[0047] Potassium Chloride 3.3%

[0048]water 8%

[0049] 1. Dissolve 24 grams of soybean protein isolate in 1100 mL of water for dispersion, heat treatment at 90°C for 35 minutes, adjust the pH of the solution to 10 with 0.1N sodium hydroxide, add 36 grams of 40-mesh CMKGM and 3 mL of phosphorus oxychloride, and copolymerize for 3 hours. Precipitate, wash and dry to obtain the CMKGM-SPI complex.

[0050] 2. Mix 32 grams of CMKGM-SPI compound with a particle size of 40 mesh with 568 mL of water under stirring, continue to stir and disperse, and fully swell at 55-60 ° C for 40-60 minutes. to form a homogeneous sol

[0051] 3. Weigh 8 grams of carrageenan, pour it into 392mL of water, stir well, heat to above 60°C to dissolve evenly, and fully swell for 30-40 minutes to form a uniform sol.

...

Embodiment 2

[0055] Raw material % by weight

[0056] Oxidized Glucomannan 50.8%

[0057] Soy Protein Isolate 25.4%

[0058] Xanthan Gum 12.0%

[0059] Potassium Phosphate 3.8%

[0060] water 8%

[0061] 1. Dissolve 30 grams of soybean protein isolate in 1000 mL of water for dispersion, heat treatment at 100 ° C for 30 minutes, adjust the pH of the solution to 9 with 0.1 N sodium hydroxide, add 60 grams of 40-mesh oxidized glucomannan OKGM and 2.5 grams of sodium trimetaphosphate , copolymerization reaction for 2 hours. Precipitate, wash and dry to obtain the OKGM-SPI complex.

[0062] 2. Mix 34.5 grams of OKGM-SPI compound with a particle size of 40 mesh with 665.5 mL of water under stirring, continue to stir and disperse, and swell at 60°C for 40 minutes. to form a homogeneous sol

[0063] 3. Weigh 5.43 grams of xanthan gum, pour it into 294.5 mL of water, stir evenly, heat to above 70°C to dissolve evenly, and fully swell for 1 hour...

Embodiment 3

[0067] Raw material % by weight

[0068] Maleic Anhydride Glucomannan 32%

[0069] Soy Protein Isolate 32%

[0070] Carrageenan 27.5%

[0071] Potassium Citrate 5.1%

[0072] Water 3.4%

[0073] 1. Dissolve 32 grams of soybean protein isolate in 1000 mL of water for dispersion, heat treatment at 100 ° C for 30 minutes, adjust the pH of the solution to 9 with 0.1 N sodium hydroxide, add 32 grams of 40 mesh maleic anhydride esterified glucomannan and 1.5 mL of three Phosphorus oxychloride, copolymerization reaction for 3 hours. Precipitate, wash and dry to obtain esterified konjac glucomannan-soybean protein isolate complex.

[0074] 2. Mix 56 grams of the esterified konjac glucomannan-soybean protein isolate complex with a particle size of 40 meshes with 1144 mL of water under stirring, continue to stir and disperse, and swell at 60° C. for 50 minutes. to form a homogeneous sol.

[0075] 3. Weigh 24 ...

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PUM

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Abstract

A vegetative capsule shell is prepared through gelatinizing konjak starch, adding emulsifier, reaction, washing, drying, pulverizing to obtain modified product, gelatinizing soybean p rotein, thermal modifying, regulating pH value, adding said modified product and cross-linking agent, copolymerizing, mixing it with coagulant and solidifying aid, stirring, using template to dip in it, baking, drawing shell, and cutting.

Description

technical field [0001] The invention relates to a film-forming complex of modified konjac glucomannan and soybean protein isolate, preferably carboxymethyl konjac glucomannan-soybean protein isolate complex (CMKGM-SPI complex), which is used for medicine, Veterinary, food, cosmetic or other film-like products. More specifically, it relates to a plant hard hollow capsule, and also relates to a preparation method of the plant hard hollow capsule. Preference is given to pre-dose formulations, such as hard capsule formulations. The hard hollow capsule obtained by the present invention is similar to the gelatin hard hollow capsule, and its performance is better than that of the gelatin hard hollow capsule. Background technique [0002] The industrial manufacture of traditional hard hollow capsules is the most preferred gelatin, which is due to its characteristics of gelling, film-forming and surface activity. Gelatin hard hollow capsules have certain ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48
Inventor 姜发堂张小菊
Owner 湖北工学院
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