Liquid capsule and production method thereof

A liquid capsule and liquid technology, applied in the direction of capsule transportation, can solve the problems of slow dissolution of active ingredients, difficulty in formulation development, and migration of capsule substances, and achieve the effects of good heat resistance, crystal clear appearance, and high bioavailability.

Inactive Publication Date: 2005-01-26
HAINAN PULIN PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional capsules include hard capsules (suitable for filling powder or granular drugs) and soft capsules (suitable for liquid drugs such as fish oil, vitamin E, and vitamin A). Some drugs are easily affected by temperature, oxygen, and heavy metals. Moreover, the drug is easy to seep out from the auxiliary materials such as the absorbent, so that the main drug is lost and the curative effect is affected.
There are also some insoluble drugs whose active ingredients dissolve slowly and cannot take effect in time. For these drugs, soft capsule dosage forms are generally used, but soft capsules have some stability problems, such as disintegration during storage. Migration and other phenomena make formulation development difficult

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Preparation of silymarin liquid capsules (Yiganling liquid capsules)

[0013] Prescription: Silymarin 125g

[0014] Beeswax 30g

[0015] soybean oil 360g

[0016] Lecithin 35g

[0017] Makes 1000 capsules

[0018] Preparation Process:

[0019] ①Crush the silymarin raw material through a 100-mesh sieve.

[0020] ② Add 30 grams of beeswax and 35 grams of lecithin to 350 grams of soybean oil, heat to about 50-60 degrees, and stir evenly;

[0021] ③ Slowly add 125 grams of silymarin into the above solution and stir evenly;

[0022] ④ Fill it into capsules while it is hot, 550mg per capsule, and seal it.

Embodiment 2

[0024] Preparation of Coenzyme Q 10 liquid capsule

[0025] Prescription: Coenzyme Q 10 30g

[0026] soybean oil 450g

[0027] Lecithin 50g

[0028] Makes 1000 capsules

[0029] Preparation Process:

[0030] ①Crush the coenzyme Q10 raw material through a 100-mesh sieve.

[0031] ② Weigh 450 grams of soybean oil and 50 grams of lecithin, heat to about 40-50 ° C, and stir evenly;

[0032] ③ Slowly add 30 grams of coenzyme Q10 to the above solution and stir evenly;

[0033] ④ Fill it into capsules while it is hot, 530mg per capsule, and seal it.

Embodiment 3

[0035] Preparing Valerian Liquid Capsules

[0036] Prescription: Valerian 125g

[0037] soybean oil 370g

[0038] Lecithin 45g

[0039] Makes 1000 capsules

[0040] Preparation Process:

[0041] ①Crush the valerian root material through a 100-mesh sieve.

[0042] ② Weigh 370 grams of soybean oil and 45 grams of lecithin, heat to about 40-50 ° C, and stir evenly;

[0043] ③ Slowly add 125 grams of valerian into the above solution and stir evenly;

[0044] ④ Fill it into capsules while it is hot, 540mg per capsule, and seal it.

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PUM

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Abstract

The invention provides a liquid capsule which comprises a medicament layer as the active constituent, auxiliary material and capsule shell, whose content in liquid or semi-solid form.

Description

technical field [0001] The invention relates to a liquid capsule and a preparation method thereof. Background technique [0002] At present, among the oral dosage forms of drugs, capsules are quite popular among consumers because they are more convenient to carry and take. Traditional capsules include hard capsules (suitable for filling powder or granular drugs) and soft capsules (suitable for liquid drugs such as fish oil, vitamin E, and vitamin A). Some drugs are easily affected by temperature, oxygen, and heavy metals. And medicine is easy to ooze out from auxiliary materials such as absorbent, makes main medicine loss, influences curative effect. There are also some insoluble drugs whose active ingredients dissolve slowly and cannot take effect in time. For these drugs, soft capsule dosage forms are generally used, but soft capsules have some stability problems, such as disintegration during storage. Phenomena such as migration make formulation ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48
Inventor 范敏华
Owner HAINAN PULIN PHARMA
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