Biological collagen hemostatic cotton and its preparation method

A production process and bio-adhesive technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of inability to achieve rapid hemostasis, poor wound deformation, partial filling transition or insufficient filling, etc., to promote wound healing. , The effect of strong deformation ability and fast filling speed

Inactive Publication Date: 2005-01-26
珠海百辉医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The inventor once applied for an invention patent with the application number 01133795.8 and the name "New Technology of Surgical Absorbable Hemostatic Sponge", which discloses a medical gelatin sponge and its production process. The gelatin sponge can be used for hemostasis during surgical operations. It can also be used to fill wounds to stop bleeding during trauma, but because the above-mentioned hemostatic sponge is actually a gelatin fiber block with micropores, its edges and corners are relatively obvious, and the ability to deform with the wound is poor when filling the wound, and it cannot completely match the wound when filling. Only when the shape of this hemostatic sponge is basically the same as the shape of the wound can its filling and hemostatic effect meet the requirements, otherwise it will cause local filling transition or insufficient filling, and the effect of rapid hemostasis in a short period of time cannot be achieved, and it is also harmful to the Subsequent wound healing is also detrimental
In order to solve the above problems, the inventor has applied for an invention patent with application number 03117311.x and titled "Bioabsorbable hemostatic sponge and its production process", which discloses a hemostatic sponge in the shape of scattered cotton , the hemostatic sponge has no fixed shape, so it is easy to fill according to the shape of the wound when filling, and its filling effect is not affected by the shape of the wound. When hemostasis of large open wounds, the effects of blocking, filling and hemostasis cannot meet the requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] 1) 3300 grams of biological glue are produced by the process with application number 03117311.x;

[0008] 2) 900 grams of bioabsorbable hemostatic sponges were prepared by spray-drying 3000 grams of the above biological glue;

[0009] 3) directly drying 300 grams of the above biological glue to obtain 90 grams of biological collagen;

[0010] 4) Grinding the above-mentioned bio-collagen into 500-mesh collagen dry powder for later use;

[0011] 5) Stir and mix the prepared collagen dry powder with the bioabsorbable hemostatic sponge, then fill it into a mold and press it;

[0012] 6) Dry the stamped bio-collagen hemostatic sponge at a high temperature of 150 degrees.

[0013] 27 cases were clinically rescued with the above products, of which 3 cases were knife wounds, 5 cases were construction injuries, 6 cases were sharp iron stab wounds, 2 cases were mountaineering falls, 11 cases were traffic accident injuries, and the wounds were all open Trauma, the deepest wound...

Embodiment 2

[0015] 1) 3400 grams of biological glue were produced by the process with application number 03117311.x;

[0016] 2) 900 grams of bioabsorbable hemostatic sponges were prepared by spray-drying 3000 grams of the above biological glue;

[0017] 3) directly drying 400 grams of the above biological glue to obtain 120 grams of biological collagen;

[0018] 4) Grinding the above-mentioned bio-collagen into 200-mesh collagen dry powder for later use;

[0019] 5) Stir and mix the prepared collagen dry powder with the bioabsorbable hemostatic sponge, then fill it into a mold and punch it into a cotton sheet;

[0020] 6) Dry the stamped bio-collagen hemostatic sponge sheet at a high temperature of 120 degrees.

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Abstract

The invention concerns a biological collagen bleeding arresting cotton by making biological collagen as raw material and its preparation process. The production steps are as follows: 1.grinding the bio-collagen into powder with 200-800 meshes 2. mixing the bio-collagen powder with bio-absorbing bleeding arresting cotton in weight ration as 0.5-1.5:9, then packing into the die and pressing 3. placing the compressed module of the bio-collagen bleeding arresting under 120-170 centigrade to make it dry. The bio-collagen bleeding arresting cotton is made by complete absorptive biological protein collagen, having no bacterial endotoxin, no pyrogen, no virus and no side effects. In addition, it can solve in the warm water with the temperature being 35íµ also, and can promote the platelet to form a tampon within 30 seconds to exert arresting the bleeding. The biological protein collagen can induce the growth factor transmigration, promote the regeneration of the injured tissue and accelerate the wound healing. In addition, it can be absorbed by the human body during the wound healing up process.

Description

(1) Technical field: [0001] The invention relates to a biological collagen hemostatic sponge produced by using biological collagen as a raw material and a production process thereof. (two) background technology: [0002] The inventor once applied for an invention patent with the application number 01133795.8 and the name "New Technology of Surgical Absorbable Hemostatic Sponge", which discloses a medical gelatin sponge and its production process. The gelatin sponge can be used for hemostasis during surgical operations. It can also be used to fill wounds to stop bleeding during trauma, but because the above-mentioned hemostatic sponge is actually a gelatin fiber block with micropores, its edges and corners are relatively obvious, and the ability to deform with the wound is poor when filling the wound, and it cannot completely match the wound when filling. Only when the shape of this hemostatic sponge is basically the same as the shape of the wound can its filling and hemostat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/16A61L15/64
Inventor 唐宝辉
Owner 珠海百辉医药科技有限公司
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