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Method for preparing acellular dermal matrix material

A technology of acellular dermis and matrix materials, which is applied in the field of manufacturing acellular dermal matrix materials, can solve the problems of long cycle, no large-scale industrial production, inability to ensure the quality and performance of target materials, etc., and achieves the effect of a simple method.

Inactive Publication Date: 2005-01-26
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The existing acellular dermal matrix materials are generally in the stage of experimental research, and there are no reports of large-scale industrial production, and there are the following deficiencies:
[0008] 1. The operation is complicated, the cycle is long, labor-intensive and time-consuming;
[0009] 2. Most of them are manually operated, and the labor intensity is high;
[0010] 3. There are a lot of hair roots and other impurities in the matrix material;
[0011] 4. Without standardized preparation process and special equipment and materials, the quality and performance of target materials cannot be guaranteed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) Cleaning: select healthy pigs, slaughter them, peel off their skins, take 100kg of fresh pigskin, put them into the drum, add 200kg of normal temperature water, cover the drum door, and rotate for 60 minutes. Drain waste. Add 200kg of normal temperature water, cover the drum door, rotate for 60min, control the waste liquid, and repeat the operation 3 times. Then rinse well.

[0041] (2) Pre-degreasing: Preheat and adjust the temperature with hot water at a temperature of 40°C, so that the temperature of the liquid in the drum reaches 36°C. Control dry. Add 200kg of hot water at a temperature of 36°C, 3.0kg of Pingpingjia, 2.5kg of soda ash and 0.4kg of penetrant JFC, and rotate for 40 minutes. Drain waste. Add 200 kg of hot water at a temperature of 30°C, rotate for 40 minutes, and dry the waste liquid. Then add 300kg of hot water at 30°C and rotate for 40 minutes. Control the waste liquid, and repeat the operation 3 times.

[0042] (3) Secondary degreasing: ...

Embodiment 2

[0053] (1) Cleaning: select healthy goats, slaughter them, peel off their skins, take 100kg of fresh goat skins, put them into the drum, add 350kg of normal temperature water, cover the drum door, and rotate for 90min. Drain waste. Add 350kg of normal temperature water, cover the drum door, rotate for 90min, control the waste liquid, and repeat the operation 4 times. Then rinse well.

[0054] (2) Pre-degreasing: Preheat and adjust the temperature with hot water with a temperature of 45°C, so that the temperature of the liquid in the drum reaches 3g°C. Control dry. Add 350kg of hot water at a temperature of 38°C, add 7.0kg of Pingpingjia, 6.5kg of soda ash and 0.7kg of penetrant JFC, and rotate for 75min. Drain waste. Add 400 kg of hot water at a temperature of 34°C, rotate for 75 minutes, and dry the waste liquid. Then add 400 kg of hot water at 34°C and rotate for 75 minutes. Control the waste liquid, and repeat the operation 4 times.

[0055] (3) Secondary degreasing:...

Embodiment 3

[0066] (1) Cleaning: select healthy cattle, slaughter them, peel off their skins, take 100kg of fresh cattle hides, put them into the drum, add 500kg of normal temperature water, cover the drum door, and rotate for 150min. Drain waste. Add 500kg of normal temperature water, cover the door of the drum, rotate it for 150min, control the waste liquid, and repeat the operation 5 times. Then rinse well.

[0067] (2) Pre-degreasing: Preheat and adjust the temperature with hot water at a temperature of 48°C, so that the temperature of the liquid in the drum reaches 42°C. Control dry. Add 500kg of hot water at a temperature of 42°C, add 10.0kg of Pingpingjia, 12.0kg of soda ash and 1.0kg of penetrant JFC, and rotate for 120min. Drain waste. Add 600kg of hot water at a temperature of 36°C, rotate for 120min, and dry the waste liquid. Then add 600kg of hot water at 36°C and rotate for 120min. Control the waste liquid, and repeat the operation 5 times.

[0068] (3) Secondary degre...

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PUM

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Abstract

A preparation process for decell corium substrate material is disclosed. It is characterized in its process: selecting healthy animals, conducting physical and chemical treatment to raw hide within 3 hours after killing and peeling, coat shedding, purifying by compound enzyme skin collagen treatment agent, alkaline and other chemical substance. The obtained decell corium substrate material has favorable biocompatibility and appropriate biodegradation velocity. The material can be used for corium substitute, ulcer and skin habilitation, plastic surgery, beautifying and other medical purpose.

Description

1. Technical field [0001] The invention relates to a method for manufacturing an acellular cortical matrix material, which belongs to the field of biomedical material processing. 2. Background technology [0002] Whether it is war or peacetime, there will always be wounds left by burns, wounds or war injuries, so wound repair has become an eternal theme of medical treatment. With the continuous development and progress of science and technology, more and more materials can be used for wound repair, such as autologous skin, allogeneic skin, artificial skin and biological dressings. Although the existing wound repair materials have a certain rehabilitation effect, they still cannot meet the clinical needs. [0003] Acellular dermal matrix material (acellular dermal matrix, ADM) is a dermal substitute that has been clinically used in the field of burns and plastic surgery in recent years. Its raw material is allograft skin and xenograft skin. [0004] AlloDerm produced by Ame...

Claims

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Application Information

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IPC IPC(8): A61L27/60
Inventor 但卫华廖隆理李志强陈敏曾睿王坤余但年华
Owner SICHUAN UNIV
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