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Use of emodin in preparation of antagonistic TGF beta-1 and medicines to prevent tissues from fibrosis

A technique for tissue fibrosis and emodin, applied in the field of emodin

Inactive Publication Date: 2005-02-23
KIDNEY DISEASES INST P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report about the effect of emodin on antagonizing TGFβ1

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1 Emodin inhibits the expression of TGFβ1 in renal tissue of rat interstitial nephritis model, and improves renal interstitial fibrosis.

[0012] 1.1 Experimental grouping and processing:

[0013] Model group (n=8): unilateral ureteral obstruction model, with oral feeding with the same solvent as control, twice a day.

[0014] Emodin treatment group (n=8): Emodin 150mg / kg / d, orally fed twice, starting 24 hours after unilateral ureteral obstruction.

[0015] The treatment observation time was 14 days.

[0016] 1.2 Observation content and quantitative detection method

[0017] 1.2.1 Quantification of TGFβ1 expression:

[0018] ● Immunofluorescence staining was performed on TGFβ1. Under a confocal microscope with a 20x objective lens, 5 fields of cortical interstitium were continuously observed in each slice, and the total fluorescence intensity of the immunofluorescence staining was calculated.

[0019] 1.2.2 Quantification of tubulointerstitial fibrosis:

[...

Embodiment 2

[0041] Example 2. Combined application of emodin, tripterygium glycosides and benazepril inhibits the expression of TGFβ1 in renal tissue of patients with IgA nephritis, and reduces the accumulation of extracellular matrix in the glomerular mesangial area and renal interstitial fibrosis.

[0042] 2.1 Case selection

[0043] Research objects: Patients diagnosed with primary IgA nephropathy by renal biopsy combined with clinical diagnosis.

[0044] Inclusion criteria: age 14-55 years old, 24-hour urine protein quantity over 1g for more than 3 months, serum creatinine <267umol / L, no immunosuppressant, ACEI or ARB treatment within half a year.

[0045] 2.2 Grouping:

[0046] Treatment group: combined treatment with emodin, tripterygium glycosides and benazepril. Emodin 100mg, 2 times a day; tripterygium glycosides 40mg, 3 times a day; benazepril 10mg, 1 time a day.

[0047] Control group: combined treatment with prednisone and benazepril, prednisone 1mg / kg / day; benazepril 10mg,...

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Abstract

An application of the archin in preparing the medicine for suppressing TGF beta-1 and preventing the tissue fibrosis caused by TGF beta-1 is disclosed.

Description

technical field [0001] The present invention relates to emodin, and specifically relates to the application of emodin in the preparation of drugs for antagonizing TGFβ1 and preventing tissue fibrosis. Background technique [0002] TGFβ1 (transforming growth factor β1) is an important fibrogenic factor in various chronic organ diseases (such as renal cirrhosis, liver cirrhosis, pulmonary fibrosis). It participates in the process of tissue fibrosis by promoting apoptosis, increasing the production of extracellular matrix, and inducing epithelial-mesenchymal transition. Although it has been reported that anti-TGFβ1 antibodies, decorin (decorin), bican (disaccharides), soluble TGFβ1 receptors, etc. can antagonize or partially antagonize TGFβ1, but due to their heterogeneous origin and uncertain curative effect, so far Not for clinical application. [0003] Emodin is a product isolated from natural medicines. Its raw materials are rich in sources and its separation technology ...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61P1/16A61P11/00A61P13/12A61P43/00
Inventor 黎磊石
Owner KIDNEY DISEASES INST P L A
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