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Oral disintegrants of quick acting on heart and their preparation

An orally disintegrating tablet and technology for disintegrating tablets, applied in the field of Suxiao Jiuxin orally disintegrating tablets and its preparation, can solve the problems of incomplete extraction of alkaloids and organic acids

Inactive Publication Date: 2005-02-23
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through experiments, we found that even if a carrier agent is added in the supercritical extraction, a large amount of ligustrazine and ferulic acid can still be detected in the dregs, which shows that supercritical extraction has a great effect on the polar alkaloids and organic acids. very incomplete extraction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] (1) The raw materials and medicinal materials of the disintegrating tablet are composed by weight: Rhizoma Chuanxiong 22g and Borneol 1.8g

[0097] (2) Take the Rhizoma Chuanxiong medicinal material, pulverize it, pass through a 20-mesh sieve, put it into the extraction kettle of a supercritical extraction device, and extract it at 12Mpa and 60° C. for 2 hours to obtain a supercritical extract 0.76;

[0098] (3) the above-mentioned medicinal residues are extracted twice with the acidic ethanol of 90% pH5.5 as a solvent with a multifunctional extractor; each time adding a solvent equivalent to 6 times the weight of medicinal materials; the first extraction is 2 hours, the second Extract for 1 hour; combine the ethanol extracts, filter, and concentrate the filtrate until there is no alcohol smell; wash with 6 times the amount of water on the macroporous adsorption resin, and then elute with 80% ethanol; collect the ethanol eluate, Concentrate to the extract that relative ...

Embodiment 2

[0108] (1) The raw materials and medicinal materials of the disintegrating tablet are composed in parts by weight: Rhizoma Chuanxiong 30g and Borneol 1.6g

[0109] (2) Take the Rhizoma Chuanxiong medicinal material, pulverize it, pass through a 40-mesh sieve, put it into the extraction kettle of a supercritical extraction device, and extract it at 25Mpa and 50° C. for 1.5 hours to obtain 1.14 g of supercritical extract;

[0110] (3) With the above-mentioned medicinal residues, use the acidic ethanol of 80% pH4 as a solvent and extract twice with a multifunctional extractor; each time add a solvent equivalent to 8 times the weight of medicinal materials; extract for the first time for 3 hours, and extract for the second time 2 hours; combine the ethanol extracts, filter, and concentrate the filtrate until there is no alcohol smell; wash with 3 times the amount of water on the macroporous adsorption resin, and then elute with 40% ethanol; collect the ethanol eluate, and concentra...

Embodiment 3

[0120] (1) The raw materials and medicinal materials of the disintegrating tablet are composed by weight: Rhizoma Chuanxiong 46g and Borneol 1.5g

[0121] (2) Take the Rhizoma Chuanxiong medicinal material, pulverize it, pass through a 30-mesh sieve, put it into the extraction kettle of a supercritical extraction device, and extract 3 hours at 40Mpa and 40° C. to obtain 1.96 g of a supercritical extract;

[0122] (3) With the above-mentioned medicinal residues, use the acidic ethanol of 75% pH4 as a solvent and extract twice with a multifunctional extractor; each time add a solvent equivalent to 10 times the weight of the medicinal material; extract for the first time for 2 hours, and extract for the second time 1 hour; combine the ethanol extracts, filter, and concentrate the filtrate until there is no alcohol smell; wash with 4 times the amount of water on the macroporous adsorption resin, and then elute with 60% ethanol; collect the ethanol eluate, and concentrate to Relati...

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PUM

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Abstract

A Chinese medicine in the form of oral disintegrating tablet for the first aid of heart disease is prepared from Chuan-xiong rhizome and borneol through supercritical extracting, extracting in acidic alcohol, and inclusion with borneol and cyclodextrin.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a quick-acting Jiuxin orally disintegrating tablet and a preparation method thereof. technical background [0002] Suxiao Jiuxin Pill, which is made from Rhizoma Chuanxiong and Borneol for treating coronary heart disease and angina pectoris, has been on the market for more than 20 years and has saved tens of millions of lives from death, showing a good therapeutic effect. Ligusticum chuanxiong contains alkaloid substances with ligustrazine as the main component, volatile substances with artebenolactone as the main component, and organic acids with ferulic acid as the main component; Suxiao Jiuxin Pills, the alkaloid compound with ligustrazine as the main active ingredient is obtained by using alcohol extraction, and the concentrated water solution is made acidic and extracted with chloroform to remove impurities; with the development of the times,...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61P9/10
Inventor 张晴龙
Owner 张晴龙