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Fat emulsion injection of bulleyaconitine A and its manufacturing method

A technology of sulfamethoxazole and a production method, which is applied in the directions of emulsion delivery, pharmaceutical formulations, organic active ingredients, etc., can solve the problems of poor patient compliance, slow onset of action, unable to meet the needs of fast and effective treatment of critically ill patients, etc. The product is stable and reliable

Inactive Publication Date: 2005-04-06
KUNMING ZIJIAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned oral preparations have the defects of slow onset of effect and poor patient compliance such as mouth numbness during oral administration
Therefore, the existing pharmaceutical preparations have been unable to meet the needs of fast and effective treatment of critically ill patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] formula:

[0026] Aconitin 0.1g Soybean Oil 7500g

[0027] Glycerin 1250g Soy Lecithin 750g

[0028] Preparation process: Under the condition of 100 grades, firstly dissolve aconitin in an appropriate amount of glycerin, and pay attention to make it completely dissolved. Under the protection of nitrogen, soybean lecithin was added to 20000ml of water for injection, and then the glycerin and soybean oil were added, and the water for injection was supplemented to 50000ml. At 70-80°C, use a tissue crushing mechanism to obtain rough milk. The coarse milk is rapidly cooled to below 20°C, and then emulsified with a two-step high-pressure homogenizer to obtain a finely dispersed submicron emulsion (fat emulsion). Filter with No. 4 vertical melting funnel, and the fine filtrate is sent to the subpackaging machine, divided into 50ml per bottle, capped, packaged, and tested to obtain 1000 bottles of 50ml: 0.1mg Aconitin fat emulsion infusion finished product.

Embodiment 2

[0030] formula:

[0031] Aconitin 0.2g Safflower Oil 6000g

[0032] Glycerin 1000g Low Fat Pectin 700g

[0033] Preparation process: under the condition of 100 grades, firstly dissolve aconitin in an appropriate amount of safflower oil, and pay attention to make it completely dissolved. Under nitrogen protection, add low-fat pectin to 20000ml of water for injection, then add aconitin safflower oil and glycerin, and add water for injection to 50000ml. At 70-80°C, use a tissue crushing mechanism to obtain rough milk. The coarse milk is rapidly cooled to below 20°C, and then emulsified with a two-step high-pressure homogenizer to obtain a finely dispersed submicron emulsion (fat emulsion). Filter with No. 4 vertical melting funnel, and the fine filtrate is sent to the subpackaging machine, divided into 50ml per bottle, capped, packaged, and tested to obtain 1000 bottles of 50ml: 0.2mg Aconitin fat emulsion infusion finished product.

Embodiment 3

[0035] formula:

[0036] Aconitin 0.1g Sesame Oil 6500g

[0037] Evening Primrose Oil 1000g Glycerin 1200g

[0038] Soy Lecithin 700g

[0039] Preparation process: Under the condition of 100 grades, firstly dissolve aconitin in an appropriate amount of glycerin, and pay attention to make it completely dissolved. Under the protection of nitrogen, soybean lecithin was added to 20000ml of water for injection, and then the glycerol solution of aconitin, evening primrose oil and sesame oil were added, and the water for injection was added to 50000ml. At 70-80°C, use a tissue crushing mechanism to obtain rough milk. The coarse milk is rapidly cooled to below 20°C, and then emulsified with a two-step high-pressure homogenizer to obtain a finely dispersed submicron emulsion (fat emulsion). Filter with No. 4 vertical melting funnel, and the fine filtrate is sent to the subpackaging machine, divided into 50ml per bottle, capped, packaged, and tested to obtain 1000 bottles of 50ml: 0...

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PUM

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Abstract

The invention provides a bulleyaconitine fat emulsion transfusion and its producing method, including effective component, medicinal auxiliary and emulsifier, and its characteristic: it uses bulleyaconitine as the effective component, contains 0.1-0.8mg of bulleyaconitine per bottle, and mixes in a proper amount of medicinal auxiliary and emulsifier to prepare the medicinally acceptable fat emulsion. At normal temperature, the emulsion can be placed for 1 year, stable and reliable, and through stimulative test on big white rabbits, the stimulative property of the emulsion is grade 0-1 and has better antiphlogistic and analgesic effect and energy supplementing effect and simultaneously, quickly takes effect and has good compliance of patient.

Description

technical field [0001] The invention relates to an aconitin fat emulsion infusion and a production method thereof, belonging to the production and processing of pharmaceutical preparations. Background technique [0002] Large-volume injection (referred to as infusion) is one of the more commonly used and more important dosage forms. It plays an extremely important role in the treatment of critically ill patients. With the development of medical technology and economy, the requirements of the medical department for infusion are also constantly increasing. The United States, Britain and other countries began to study high-energy fat emulsions for intravenous injection in the 1930s, and it was not until 1957 that Upjohn Company officially provided fat emulsions for intravenous injection for clinical application. China began to produce fat milk in an imported way in 1980. However, most of the fat emulsion infusions can only be used as nutritional support agents so far, and ca...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/439
Inventor 余娟
Owner KUNMING ZIJIAN BIOTECH
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