Human source anti-hepatitis A virus gene engineering antibody from CHO cell

A technology of genetic engineering antibody and hepatitis A virus, which is applied in the direction of genetic engineering, antiviral immunoglobulin, antibody, etc., and can solve problems such as immune diseases and antibody failure
CN1605628AInactive Publication Date: 2005-04-13中国疾病预防控制中心病毒病预防控制所
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
中国疾病预防控制中心病毒病预防控制所
Publication Date
2005-04-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The human-derived anti-Hepatitis A virus genetically engineered antibody produced by CHO cells includes two strains of human-derived anti-Hepatitis A virus neutralizing genetically engineered antibody CHO (Chinese hamster ovary cell) production cell line and the production of human-derived anti-Hepatitis A virus neutralizing for prevention and treatment Genetically engineered antibody preparations. Its product features are fully human antibodies IgG1λ and IgG1κ derived from phage human antibody library screening and human IgG Fc gene recombination in Chinese hamster ovary (CHO) cells stably expressing cells, named ChHAIgG16 and ChHAIgG78 respectively. The molecular weight is about 150kd. The cocktail-type antibody preparation composed of ChHAIgG16 and ChHAIgG78 mixed at a ratio of 3:1 is named HAMaxTMM. Utilizing its functional characteristics of highly neutralizing hepatitis A virus infection and the molecular structure characteristics of whole antibodies similar to natural antibody molecules, it is expected to replace blood product gamma globulin in clinical practice for the prevention and treatment of hepatitis A caused by hepatitis A virus infection .
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Description

1. Technical field

[0001] The invention belongs to the technical fields of bioengineering and biopharmaceuticals. 2. Background technology

[0002] The invention includes two strains of human anti-hepatitis A virus neutralizing genetic engineering antibodies. respectively by China Production in murine ovary cell (CHO) production cell lines. The antibody and its preparation can be used to prepare medicines or reagents for diagnosing, preventing and treating hepatitis A caused by hepatitis A virus infection.

[0003] The number of deaths caused by infectious diseases still ranks first in the world's death population, and viral hepatitis is an infectious disease that seriously endangers the health of our people. Among the infectious diseases notifiable by law, the acute and chronic hepatitis caused by various hepatitis viruses ranks first in the morbidity and mortality of all infectious diseases in my country. Hepatitis A (Hepatitis A) is an acute infectious disease caused...

Claims

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