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Igamete recruitment and developmental competence in mammals by inhibiting the de novo sterol biosynthesis and/or promoting sterol efflux

A mammalian, biosynthetic approach to gamete recruitment and developmental competence in mammals - by inhibiting de novo sterol biosynthesis and/or promoting sterol efflux, able to address unpublished cholesterol dynamics issues

Inactive Publication Date: 2005-05-25
HOSPITAL OF COPENHAGEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0030] Nothing is currently published regarding cholesterol content, cholesterol biosynthesis, and cholesterol kinetics in mammalian oocytes

Method used

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  • Igamete recruitment and developmental competence in mammals by inhibiting the de novo sterol biosynthesis and/or promoting sterol efflux
  • Igamete recruitment and developmental competence in mammals by inhibiting the de novo sterol biosynthesis and/or promoting sterol efflux
  • Igamete recruitment and developmental competence in mammals by inhibiting the de novo sterol biosynthesis and/or promoting sterol efflux

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Embodiment Construction

[0038] In its broadest aspect, the invention relates to methods of inhibiting de novo sterol biosynthesis, the effect of which is to reduce the sterol content of germ cells and possibly reduce the relationship between free sterols and phospholipids in at least one mammalian germ cell and / or gamete. thereby increasing the developmental capacity of at least one mammalian germ cell, gamete, zygote, early embryo, blastocyst, implanted blastocyst and / or embryo, and / or mammalian gamete, zygote, early embryo, The number of blastocysts, embryos and / or fetuses implanted, the method comprising administering to a mammal in need thereof a compound capable of inhibiting de novo sterol biosynthesis.

[0039] In another aspect, the present invention relates to a method of increasing sterol efflux to cells of ovarian origin surrounding at least one mammalian ovary and / or one mammalian oocyte and / or mammalian female gametes and / or the oocyte, whereby Improving the developmental capacity of the...

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Abstract

The present invention relates to methods for increasing the developmental competence of at least one mammalian germ cell, gamete, zygote, early embryo, implanted blastocyst and / or embryo by administrating a compound which is capable of inhibiting the de novo biosynthesis of sterols and thereby establishing cellular conditions that improve their development and survival. The invention also relates to methods for increasing the sterol efflux prior to fertilisation from at least one mammalian ovary, oocyte, female gamete, or ovary derived cell surrounding an oocyte by administrating a compound which is capable of promoting the sterol efflux and thereby reducing the phopholipid / sterol ratio of said cells.

Description

field of invention [0001] The present invention relates to the establishment of cellular conditions that improve the development and survival of at least one mammalian germ cell, gamete, zygote, early embryo, implanted blastocyst and / or embryo by administering a compound capable of inhibiting de novo sterol biosynthesis, Ways to improve their developmental abilities. The invention also relates to increasing sterol efflux in at least one mammalian ovary, oocyte, female gamete, or ovarian-derived cells surrounding the oocyte prior to fertilization by administering a compound capable of promoting sterol efflux, thereby reducing the phospholipids of the cells / sterol ratio method. Background of the invention [0002] Medical treatment of infertility has come a long way in the past decade, providing subfertile or infertile couples with the possibility of childbearing through medical intervention. However, a large number of couples do not gain any benefit from serial infertility...

Claims

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Application Information

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IPC IPC(8): A61K31/00A61K31/225A61K31/715A61K31/724A61K45/06A61P15/08C12N5/075C12N5/076
CPCA61K31/00A61K31/225A61K31/715A61K31/724A61K45/06A61P15/08C12N5/0609C12N5/061C12N2517/10A61K2300/00
Inventor M·巴尔特森
Owner HOSPITAL OF COPENHAGEN UNIV
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