Amide derivative of indole, its preparation method and application

A technology of amide derivatives and indole, which is applied in the field of indole derivatives, can solve problems such as environmental pollution, toxicity, and impact on human health, and achieve high-efficiency antifouling activity and significant bactericidal activity

Inactive Publication Date: 2005-08-10
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, by the end of the 1980s, people gradually realized that this organotin compound was highly toxic, would pollute the environment, and even affect human health through the food chain.

Method used

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  • Amide derivative of indole, its preparation method and application
  • Amide derivative of indole, its preparation method and application
  • Amide derivative of indole, its preparation method and application

Examples

Experimental program
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Embodiment Construction

[0010] 1. Preparation of dimethyl β-dithiodipropionate

[0011] Add 45.0g (0.19mol) Na to a 250ml beaker 2 S.9H 2 0 and 8.8g (0.28mol) of sulfur powder, heated to boiling until completely dissolved, and filtered with suction after cooling to obtain a red clear sodium polysulfide solution, cooled to -5~10°C for later use.

[0012] Add 200g of 10% (weight percent concentration, the same below) NaHCO successively in a 500ml three-necked flask equipped with a stirring device, a condenser, and a thermometer. 3 Aqueous solution, 21.7g (0.25mol) of methyl acrylate, cooled to -5 ~ 10 ℃ and maintained at this temperature, dropwise added the above aqueous solution of sodium polysulfide within 2 hours. After dropping, the reaction was continued for 6 h at room temperature, and the reaction ended. Leave to stand for stratification, add 120g of 1mol / L Na to the oil layer after removing the water layer 2 SO 3 aqueous solution, and then continue to react at 50°C for 3h, and the reaction...

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Abstract

An indoleamide derivative C14H14X1X2N2O2R1R2 used as antifoulant for preparing marine anti-fouling point is prepared through reaction between sodium polysulfide and methyl acrylate to obtain dimethyl dithiobipropionate, reaction on alkoxypropylamine to obtain N,N'-dialkylpropyl dithiopropanamide, and reaction on indole, haloindole, gramine, or halogramine to obtain target product.

Description

technical field [0001] The invention relates to an indole derivative, in particular to an indole amide derivative, a preparation method thereof and an application in preparation of marine antifouling paint. Background technique [0002] When fishing nets, boat bottoms, underwater facilities, etc. are exposed to seawater for a long time, the appearance and function are easily damaged by the adhesion, growth and reproduction of various marine fouling organisms on their surfaces. These marine fouling organisms include barnacles, hydra, Animals such as sea squirts, algae such as diatoms and green algae, and fungi such as bacteria and fungi. Especially when the above-mentioned marine fouling organisms adhere to the surface of the fishing net to grow and reproduce, they will block the mesh, increase the resistance, and reduce the catch; reduce the exchange of water inside and outside the aquaculture cage, reduce the dissolved oxygen content in the box, and reduce the amount of fis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D209/18C09D5/16
Inventor 于良民姜晓辉徐焕志张志明
Owner OCEAN UNIV OF CHINA
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