Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Amide derivative of indole, its preparation method and application

A technology of amide derivatives and indole, applied in the field of indole derivatives, can solve the problems of environmental pollution, toxicity, impact on human health, etc., and achieve the effects of high-efficiency antifouling activity and significant bactericidal activity

Inactive Publication Date: 2006-07-26
OCEAN UNIV OF CHINA
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, by the end of the 1980s, people gradually realized that this organotin compound was highly toxic, would pollute the environment, and even affect human health through the food chain.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Amide derivative of indole, its preparation method and application
  • Amide derivative of indole, its preparation method and application
  • Amide derivative of indole, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0010] 1. Preparation of dimethyl β-dithiodipropionate

[0011] Add 45.0g (0.19mol) Na to a 250ml beaker 2 S.9H 2 0 and 8.8g (0.28mol) of sulfur powder, heated to boiling until completely dissolved, and filtered with suction after cooling to obtain a red clear sodium polysulfide solution, cooled to -5~10°C for later use.

[0012] Add 200g of 10% (weight percent concentration, the same below) NaHCO successively in a 500ml three-necked flask equipped with a stirring device, a condenser, and a thermometer. 3 Aqueous solution, 21.7g (0.25mol) of methyl acrylate, cooled to -5 ~ 10 ℃ and maintained at this temperature, dropwise added the above aqueous solution of sodium polysulfide within 2 hours. After dropping, the reaction was continued for 6 h at room temperature, and the reaction ended. Leave to stand for stratification, add 120g of 1mol / L Na to the oil layer after removing the water layer 2 SO 3 aqueous solution, and then continue to react at 50°C for 3h, and the reaction...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
melting pointaaaaaaaaaa
Login to View More

Abstract

An indoleamide derivative C14H14X1X2N2O2R1R2 used as antifoulant for preparing marine anti-fouling point is prepared through reaction between sodium polysulfide and methyl acrylate to obtain dimethyl dithiobipropionate, reaction on alkoxypropylamine to obtain N,N'-dialkylpropyl dithiopropanamide, and reaction on indole, haloindole, gramine, or halogramine to obtain target product.

Description

technical field [0001] The invention relates to an indole derivative, in particular to an indole amide derivative, a preparation method thereof and an application in preparation of marine antifouling paint. Background technique [0002] When fishing nets, boat bottoms, underwater facilities, etc. are exposed to seawater for a long time, the appearance and function are easily damaged by the adhesion, growth and reproduction of various marine fouling organisms on their surfaces. These marine fouling organisms include barnacles, hydra, Animals such as sea squirts, algae such as diatoms and green algae, and fungi such as bacteria and fungi. Especially when the above-mentioned marine fouling organisms adhere to the surface of the fishing net to grow and reproduce, they will block the mesh, increase the resistance, and reduce the catch; reduce the exchange of water inside and outside the aquaculture cage, reduce the dissolved oxygen content in the box, and reduce the amount of fis...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D209/18C09D5/16
Inventor 于良民姜晓辉徐焕志张志明
Owner OCEAN UNIV OF CHINA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com