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Ester derivative of indole, its preparation method and application

A derivative, indole technology, applied in the field of indole derivatives, can solve problems such as toxicity, environmental pollution, and human health, and achieve high-efficiency antifouling activity and important bactericidal activity

Inactive Publication Date: 2006-07-26
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the 1980s, people gradually realized that this organotin compound was highly toxic, would pollute the environment, and even affect human health through the food chain.

Method used

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  • Ester derivative of indole, its preparation method and application
  • Ester derivative of indole, its preparation method and application
  • Ester derivative of indole, its preparation method and application

Examples

Experimental program
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Effect test

Embodiment Construction

[0010] 1. Preparation of dimethyl β-dithiodipropionate

[0011] Add 45.0g (0.19mol) Na to a 250ml beaker 2 S.9H 2 0 and 8.8g (0.28mol) of sulfur powder, heated to boiling until completely dissolved, cooled and filtered with suction to obtain a red clear sodium polysulfide solution, cooled to -5 to 10°C for later use.

[0012] Add 200g of 10% (weight percent concentration, the same below) NaHCO successively in a 500ml three-necked flask equipped with a stirring device, a condenser, and a thermometer. 3 Aqueous solution, 21.7g (0.25mol) of methyl acrylate, cooled to -5 ~ 10 ℃ and maintained at this temperature, dropwise added the above aqueous solution of sodium polysulfide within 2 hours. After dropping, the reaction was continued for 6 h at room temperature, and the reaction ended. Leave to stand for stratification, add 120g of 1mol / L Na to the oil layer after removing the water layer 2 SO 3 aqueous solution, and then continue to react at 50°C for 3h, and the reaction end...

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Abstract

An indole ester derivative C11H7X1X2NO2R1R2 used as antifoulant for anti-fouling paint is prepared through reaction between sodium polysulfide and alkyl acrylate to obtain dialkyl dithiobipropionate, and reaction on indole, haloindole, gramine, or halogramine.

Description

technical field [0001] The invention relates to an indole derivative, in particular to a preparation method of an indole ester derivative and its application in preparing marine antifouling paint. Background technique [0002] It is well known that fouling organisms such as barnacles, mussels, and seaweed often attach to ship hulls, nets, power plant cooling systems, and other underwater facilities. This attachment not only causes surface fouling of these facilities, but also accelerates corrosion rate. The most common way to tackle this type of marine biofouling is to apply paint containing antifouling agents. At present, the antifouling agents widely used at home and abroad are organic tin and cuprous oxide, that is, the copolymer of tributyltin methacrylate and methyl methacrylate and cuprous oxide (Cu 2 O) the composition is used as a kind of antifouling paint, is coated on surfaces such as the bottom of a ship, and can effectively prevent the harm of marine fouling or...

Claims

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Application Information

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IPC IPC(8): C07D209/04C07D209/14C09D5/16
Inventor 于良民姜晓辉徐焕志张志明
Owner OCEAN UNIV OF CHINA
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