Salviolic acid berberine double salt, its preparation method and application
A technology of salvianolic acid and berberine, applied in the field of salvianolic acid and berberine double salt and its preparation, to achieve the effect of improving water solubility and increasing oral absorption
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Embodiment 1
[0023] Dissolve salvianolic acid A and berberine in absolute ethanol at a weight-to-volume ratio of 1:100, mix salvianolic acid A and berberine at a molar ratio of 1:1, stir for 5 hours, precipitate out, filter conventionally, and dry That is, berberine compound salt of salvianolic acid.
Embodiment 2
[0025] Dissolve salvianolic acid B and berberine in acetone at a weight-to-volume ratio of 1:120, mix salvianolic acid B and berberine at a molar ratio of 1:1, stir for 3 hours, precipitate out, filter conventionally, and dry to obtain Salvianolic acid berberine double salt.
Embodiment 3
[0027] Acetylsalvianolic acid A magnesium salt and berberine were dissolved in methanol with a weight-to-volume ratio of 1:80, acetysalvianolic acid A magnesium salt and berberine were mixed with a molar ratio of 1:5, stirred for 3 hours, and precipitated, Routine filtration, drying to obtain salvianolic acid berberine double salt.
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