Salviolic acid berberine double salt, its preparation method and application

A technology of salvianolic acid and berberine, applied in the field of salvianolic acid and berberine double salt and its preparation, to achieve the effect of improving water solubility and increasing oral absorption

Inactive Publication Date: 2005-08-10
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, through literature search, there is no report on the research and application of salvianolic acid A or B and berberine to form a double salt as a new drug to expand the medicinal value of salvianolic acid and berberine

Method used

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  • Salviolic acid berberine double salt, its preparation method and application
  • Salviolic acid berberine double salt, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Dissolve salvianolic acid A and berberine in absolute ethanol at a weight-to-volume ratio of 1:100, mix salvianolic acid A and berberine at a molar ratio of 1:1, stir for 5 hours, precipitate out, filter conventionally, and dry That is, berberine compound salt of salvianolic acid.

Embodiment 2

[0025] Dissolve salvianolic acid B and berberine in acetone at a weight-to-volume ratio of 1:120, mix salvianolic acid B and berberine at a molar ratio of 1:1, stir for 3 hours, precipitate out, filter conventionally, and dry to obtain Salvianolic acid berberine double salt.

Embodiment 3

[0027] Acetylsalvianolic acid A magnesium salt and berberine were dissolved in methanol with a weight-to-volume ratio of 1:80, acetysalvianolic acid A magnesium salt and berberine were mixed with a molar ratio of 1:5, stirred for 3 hours, and precipitated, Routine filtration, drying to obtain salvianolic acid berberine double salt.

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PUM

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Abstract

A berberine danshinolate used to prepare the medicines for treating chronic hepatism, diabetes, and its complications is prepared from berbeine and danshinolic acid or its derivative, which includes danshinolic acid A or B or their derivatives and metallic salts, the metallic salts of the derivatives of danshinolic acid A or B, and the red sage root's extract containing danshinolic acid A or B.

Description

technical field [0001] The present invention relates to salvianolic acid medicines and its preparation method and application, in particular to a salvianolic acid berberine double salt and its preparation method and application. Background technique [0002] The water-soluble active ingredients of Salvia miltiorrhiza have strong anti-lipid peroxidation and free radical scavenging effects. The two ingredients with the highest content, salvianolic acid A and B, have the strongest activity. It plays a key role in the curative effect, not only has a certain protective effect on the cardiovascular system, but also reverses liver fibrosis in vitro (Du Guanhua, Zhang Juntian, research progress on salvianolic acid, a water-soluble active ingredient of salvia miltiorrhiza, Basic Medicine and Clinic, 2000, 20(5):394-398). Berberine is an alkaloid extracted from berberine-containing medicines such as Coptis chinensis and Cortex Phellodendri. Studies have found that it has antibacteria...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61P1/16A61P3/10C07D491/18
Inventor 娄红祥李洁范培红
Owner SHANDONG UNIV
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