Application of erigeron breviscapus aglucon in preparating medicine

A technology of scutellarin and scutellarin, which is applied to the application field of scutellarin aglycone in the pharmaceutical field, can solve the problems of no relevant reports and little research

Inactive Publication Date: 2005-08-24
车庆明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These four monomeric compounds have little research on their pharmacological effects and whether they can be applied in the field of pharmacy, and there are no related reports.

Method used

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  • Application of erigeron breviscapus aglucon in preparating medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0051] Use 2.5kg of the whole plant of Erigeron breviscapus Yunnan, add 95% ethanol to extract, dissolve the extract in hot water at 70-80°C, extract with chloroform, then extract with ether and ethyl acetate respectively, recover the solvent, and obtain a yellow precipitate. The precipitate was recrystallized from a mixed solvent of pyridine and water, and then subjected to polyamide column chromatography to obtain 2000 mg of scutellarin aglycon as a light yellow powder.

[0052] Mass spectrometry EI-MS: (M + ) 286; C NMR spectrum 13CNMR: 163.59 (C-2), 103.9 (C-3), 182.0 (C-4), 149.6 (C-5), 129.1 (C-6), 161.0 (C-7) , 93.8(C-8), 147.0(C-9), 102.4(C-10), 128.4(C-1'), 121.5(C-2'), 115.9(C-3'), 153.3(C- 4'), 115.9(C-5'), 121.5(C-6').

[0053] Proton nuclear magnetic resonance spectrum 1H-NMR: 6.73 (s, H-3), 6.57 (s, H-8), 12.77 (s, OH-5), 8.77 (s, OH-6), 10.53 (s, OH- 7), 10.37 (s, OH-4'), 7.89 (d, 2H, H-2', -6'), 6.90 (d, 2H, H-3', 5').

[0054] Breviscapine aglycon oral sol...

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Abstract

An application of breviscapine B aglycone in preparing medicines for preventing and treating cerebral apoplexy and cardiovascular and cerebrovascular diseases with high curative effect is disclosed.

Description

technical field [0001] The invention relates to the use of scutellarin aglycon (4'-hydroxybaicalein), in particular to the application of scutellarin aglycon in the pharmaceutical field. Background technique [0002] Scutellarin aglycon is a compound isolated from the whole plant of Scutellaria breviscapus, and its chemical structure is as follows: [0003] [0004] Erigeron breviscapus, also known as Erigeron breviscapus, belongs to the genus Asteraceae. It has the effects of promoting blood circulation and removing blood stasis, dispelling cold and relieving the surface, relaxing tendons and activating collaterals, expelling wind and dampness, and is often used clinically to treat cardiovascular and cerebrovascular diseases. Currently, the active ingredients of breviscapine preparations used clinically are generally extracted by ethanol and ethyl acetate, such as the breviscapine injection disclosed in CN1091301. The specific preparation method is as follows: directly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P9/10
Inventor 车庆明
Owner 车庆明
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