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Anticarcinogenic compound medicinal preparation

A technology for pharmaceutical preparations and compound recipes, applied in the field of anticancer compound pharmaceutical preparations, can solve the problems such as cyclophosphamide and matrine that have never been seen before, and achieve the effects of reducing the degree of reduction, good effect and improving activation.

Inactive Publication Date: 2005-10-12
肖春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no reports of compound drug anticancer preparations made from the combination of cyclophosphamide and matrine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Preparation of Cyclophosphamide Matrine freeze-dried powder injection

[0023] prescription:

[0024] Cyclophosphamide 50g

[0025] Matrine 600g

[0026] Mannitol 50g

[0027] Water for injection

[0028] Made into 1000 or 2000

[0029] Process:

[0030] Take 50g of cyclophosphamide, 600g of oxymatrine, and 50g of mannitol, add appropriate amount of water for injection to completely dissolve, adjust the PH value to 4.5-6.5, filter, fill; pre-freeze, cool and dry to get this product.

Embodiment 2

[0031] Example 2: Preparation of Cyclophosphamide Matrine freeze-dried powder injection

[0032] prescription:

[0033] Cyclophosphamide 100g

[0034] Matrine 600g

[0035] Sorbitol 100g

[0036] Water for injection

[0037] Made into 1000 or 2000

[0038] Process:

[0039] Take 100g of cyclophosphamide, 600g of oxymatrine, and 100g of sorbitol, add appropriate amount of water for injection to completely dissolve and dissolve, adjust the PH value to 4.0-7.0, filter, fill; pre-freeze, cool and dry to get this product.

Embodiment 3

[0040] Example 3 Preparation of cyclophosphamide matrine capsules

[0041] prescription:

[0042] Cyclophosphamide 25g

[0043] Matrine 300g

[0044] Starch 200g

[0045] Magnesium stearate 0.3g

[0046] 5% PVP soluble acid appropriate amount

[0047] Made into 1000 tablets

[0048] Process:

[0049] Take the prescription amount of cyclophosphamide and matrine, add them to starch and mix well, then add magnesium stearate, use 5% PVP solution to make soft material, pass 40 mesh sieve to granulate, dry and put into capsule.

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PUM

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Abstract

An anticancer composite medicine is proportionally prepared from sendoxan, kuraminol or its derivative and additive. Its advantages are low poison to white cells, low dosage and high curative effect.

Description

Technical field [0001] The invention relates to a compound pharmaceutical preparation, in particular to an anticancer compound pharmaceutical preparation prepared by combining cyclophosphamide and oxymatrine. Background technique [0002] Cyclophosphamide has no anti-tumor activity in vitro. After entering the body, it is first converted into aldophosphamide by microsomal functional oxidase in the liver. Aldophosphamide is unstable and decomposes into phosphoramide mustard and acrolein in tumor cells. Phosphoramide mustard has a cytotoxic effect on tumor cells. At the same time, cyclophosphamide is also one of the most powerful drugs among the various immunosuppressive agents currently used. Its immunosuppressive effect is due to its ability to inhibit cell proliferation, non-specifically killing antigen-sensitive small lymphocytes, and restricting its transformation into Immunoblasts. It is most effective when given after antigen stimulation, but it also has a certain effect to ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/10A61K9/14A61K9/16A61K9/19A61K9/20A61K9/48A61K31/4375A61K31/664A61P35/00
Inventor 肖春
Owner 肖春
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