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Glucoside extracts from figwort roof, its making method and use in preparing medicines

A technology of glycoside extract and Scrophulariaceae, applied in the field of Scrophulariaceae total glycosides extract, can solve the problems of reducing platelets and white blood cells, severe gastrointestinal reactions, bleeding tendency, etc. Good results

Active Publication Date: 2005-10-12
NANJING CORE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antiplatelet and anticoagulant agents used in Western medicine for ischemic stroke often have side effects such as severe gastrointestinal reactions, skin rashes, decreased platelets and white blood cells, and tendency to bleed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] Take Scrophulariaceae medicinal materials, add 5 times the amount of 70% ethanol to reflux extract once, each time for 1 hour, filter the extract, concentrate; add ethanol to the concentrate until the alcohol content is 40%, let it stand for precipitation, filter the supernatant, and concentrate The concentrated solution is put on the HPD-100 macroporous adsorption resin column, eluted with water until the effluent has no reducing sugar reaction, then eluted with 15 times the amount of 30% ethanol, collected the ethanol eluate, concentrated, and dried to obtain the total amount of Scrophulariaceae. Glycoside extract, wherein the content of total phenylpropanoid glycosides in Scrophulariaceae is 42.7%, and the content of total iridoid glycosides in Scrophulariaceae is 10.3%.

Embodiment 2

[0111] Take Scrophulariaceae herbs, slice them, add 10 times the amount of 90% ethanol to reflux and extract twice, each time for 2 hours, filter the extract, concentrate; add ethanol to the concentrate until the alcohol content is 60%, let it stand for precipitation, and filter the supernatant , concentrate; the concentrated solution is put on the HPD-400 macroporous adsorption resin column, eluted with water until the effluent has no reducing sugar reaction, then eluted with 10 times the amount of 60% ethanol, collected the ethanol eluate, concentrated, and dried to obtain Xuan The total glycosides extract of Radix Scrophulariae contains 45.0% of total phenylpropanoid glycosides and 12.5% ​​of total iridoid glycosides of Radix Scrophulariae.

Embodiment 3

[0113] Take the medicinal material of Scrophulariaceae Scrophulariae, crush it, add 15 times the amount of 40% ethanol to reflux and extract 3 times, each time for 3 hours, filter the extract, concentrate; add ethanol to the concentrate until the alcohol content is 80%, let it stand for precipitation, and filter the supernatant , concentrated; the concentrated solution is put on the AB-8 macroporous adsorption resin column, eluted with water until the effluent has no reducing sugar reaction, then eluted with 5 times the amount of 90% ethanol, collected the ethanol eluate, concentrated, and dried to obtain Xuan The total glycosides extract of Radix Scrophulariae contains 46.8% of total phenylpropanoid glycosides and 15.9% of total iridoid glycosides of Radix Scrophulariae.

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PUM

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Abstract

A scorphularoside for preparing the medicine to treat ischemic cerebral apoplexy is prepared from scrophularia root through extracting in alcohol, filtering, concentrating, depositing in alcohol, filtering supernatant, concentrating, chromatographing, eluting white water and then alcohol, concentrating the eluting liquid and drying.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to a total glucoside extract of Scrophulariaceae extracted and separated from the traditional Chinese medicine Scrophulariaceae for treating ischemic cerebral apoplexy. The invention also relates to a pharmaceutical composition containing the extract, the extract The preparation method and the application of the extract in pharmacy. Background technique [0002] Ischemic stroke is cerebral infarction, including cerebral thrombosis and cerebral embolism. and necrosis. Stroke is one of the most common diseases among middle-aged and elderly people. It has the characteristics of high morbidity and recurrence rate, high mortality rate and disability rate. It is one of the three major causes of death in human beings. According to statistics, the incidence of stroke in my country is 248.58 per 100,000 people, and about 2.5 million new cases are added every year; about 1...

Claims

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Application Information

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IPC IPC(8): A61P9/10
Inventor 陈彬辉何凌云王雪根王乃利任宇赵万洲李正荣
Owner NANJING CORE TECH CO LTD
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