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Compound isatis root freeze-dried powder injection and its preparing method

A technology for freeze-dried powder injection and compound isatidis, which is applied in the field of compound isatis root freeze-dried powder injection and its preparation, and can solve the requirement that no compound isatis root freeze-dried powder injection has been found, and the product quality of compound isatidis injection is unstable and preservation. higher question

Inactive Publication Date: 2005-10-19
张海峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the volatile oil and other components, the product quality of Compound Banlangen Injection is unstable, and the requirements for preservation are relatively high. Improper storage will cause turbidity, precipitation, discoloration, etc. due to oxidation; The content has been determined, which is not conducive to the control and stability of product quality
Injections are easily broken during carrying, storage, and transportation, which also brings a lot of trouble
[0007] No report on compound Radix Radix freeze-dried powder injection was found in the data retrieval

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] (1) The raw materials are: Radix Radix 500g, capillary wormwood 250g, licorice 50g.

[0049] (2) Take capillary capillary medicinal material, soak in water for 30 minutes, extract the volatile oil by steam distillation, slowly add the collected volatile oil into 10 times the amount of HP-β-CD saturated aqueous solution, stir at 50°C-60°C for 2 Hours, continued to stir at room temperature for 3 hours, refrigerated overnight, filtered, and dried to obtain 0.7 g of capillary volatile oil clathrate.

[0050] (3) Take Radix Radix Radix and add 6 times the amount of 60% ethanol to reflux to extract, and the ethanol reflux liquid is decompressed to recover ethanol and concentrate to obtain the Radix Radix Radix concentrate; the dregs of capillary root and licorice are decocted twice, for the first time for 2 hours, and for the second time After 1 hour, combine the decoction liquid, filter, concentrate the filtrate under reduced pressure, combine with Radix Radix Radix concentr...

Embodiment 2

[0054] (1) The composition by weight of the raw material drug is: 500 g of Radix Radix Radix, 250 g of capillary root, and 50 g of licorice.

[0055] (2) Take capillary capillary, soak in water for 30 minutes, extract the volatile oil by steam distillation, slowly add the collected volatile oil to 15 times the amount of HP-β-CD saturated aqueous solution, and stir for 3 hours under the condition of 50°C-60°C heat preservation , continued to stir at room temperature for 3 hours, refrigerated overnight, filtered, and dried to obtain 1.1 g of capillary volatile oil clathrate.

[0056] (3) Take Radix Radix Radix and add 5 times the amount of 65% ethanol to reflux for extraction, and the ethanol reflux liquid is decompressed to recover ethanol and concentrate to obtain Radix Radix Radix Concentrate; Capillary dregs and licorice are decocted twice, for the first time for 2 hours, and for the second time Once for 1 hour, combine the decoction liquid, filter, concentrate the filtrate ...

Embodiment 3

[0060] (1) The composition by weight of the raw material drug is: 500 g of Radix Radix Radix, 250 g of capillary root, and 50 g of licorice.

[0061] (2) Take capillary capillary, soak in water for 30 minutes, extract the volatile oil by steam distillation, slowly add the collected volatile oil to 20 times the amount of HP-β-CD saturated aqueous solution, and stir for 3 hours at 50°C-60°C , continued to stir at room temperature for 3 hours, refrigerated overnight, filtered, and dried to obtain 1.5 g of capillary volatile oil clathrate.

[0062] (3) Take Radix Radix and add 5 times the amount of 70% ethanol for reflux extraction, and the ethanol reflux liquid is decompressed to reclaim ethanol and concentrate to obtain Radix Radix concentrate; Capillary dregs and licorice are decocted twice, for the first time for 2 hours, and for the second time Once for 1 hour, combine the decoction liquid, filter, concentrate the filtrate under reduced pressure, combine with the concentrated...

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PUM

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Abstract

The present invention discloses a kind of freeze dried isatis root powder for injection and its preparation process and the freeze dried isatis root powder for injection is prepared with HP-beta-CD inclusion of extracted capillary artemisia oil in 0.5-2 weight portions, purified extract of isatis root, capillary artemisia and licorice in 30-50 weight portions, and medicinal supplementary material. The present invention features that the extract contains indirubin more than 40 ppm and indigo more than 42 ppm. Pharmaceutical experiment results show that the freeze dried isatis root powder for injection of the present invention has even high pharmaceutical effect.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a compound Radix isatidis freeze-dried powder injection and a preparation method thereof. Background technique [0002] Banlangen is the dried root of Isatis indigotica Fort., a cruciferous plant. Radix isatidis is cold in nature and bitter in taste. It has the effects of clearing away heat and detoxifying, cooling blood and relieving throat, and is used for warming toxins and spots, dark purple tongue, mumps, sore throat, rotten throat Dansha, big head plague, erysipelas, and carbuncle. [0003] Capillaris is the dried seedling of Artemisia capillaris Thumb. or Artemisia scopariaWaldst.et Kit. of Compositae. Yinchen is slightly cold in nature, bitter and pungent in the mouth. Can clear away dampness and heat, relieve jaundice. For jaundice oliguria, eczema itching; infectious jaundice hepatitis. [0004] Licorice is the dried root a...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61P11/04
Inventor 张海峰
Owner 张海峰
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