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Waveguide structure

A technology of waveguide structure and sensing layer, which is applied in the direction of optical waveguide light guide, coupling of optical waveguide, light guide, etc., can solve the problem that larger particles cannot be detected, improve surface plasmon resonance and resonant mirror technology, and manufacture cheaply , easy-to-handle effects

Inactive Publication Date: 2005-10-19
THE SEC OF STATE FOR DEFENCE IN HER BRITANNIC MAJESTYS GOVERNMENT OF THE UK OF GREAT BRITAIN & NORTHERN IRELAND
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  • Claims
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Problems solved by technology

As a result, larger particles (such as bacteria and some viruses) cannot be detected using this method

Method used

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Embodiment Construction

[0046] now refer to figure 1 , as long as the light 11 is larger than the critical angle θ of total internal reflection in the optically denser medium c The incident angle is incident to the refractive index is different (n 1 and n 2 ) on the interface 12 between the media, the evanescent field 13 will be generated due to the conservation of momentum and energy. The evanescent field or evanescent wave 13 propagates in the optically less dense medium parallel to the interface 12, and its intensity is represented by a curve, which can be expressed as:

[0047] I ev = I o exp(-z / d p )

[0048] where I o is the intensity of the evanescent wave at the reflection point, z is the distance between the evanescent wave and the reflection point, d p is the penetration depth of the evanescent wave in less optically dense media.

[0049] The penetration depth d of the evanescent wave p is the wavelength λ and angle θ of the incident light i function, and follow the relationship:...

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Abstract

A novel single point leaky waveguide structure and its use as an optical sensor for the detection of particles is disclosed. The waveguide structure is fabricated to increase the overlap of the evanescent field extension from the sensor surface with particles in the bulk solution of a flowing system so as to place most of the volume of the particles within the evanescent field. Increasing the overlap of the evanescent field with the particles and permitting mode propagation along the direction of flow for a few millimetres provides an effective interrogation approach for multiple particle detection in a single flow channel.

Description

technical field [0001] The present invention relates to waveguide structures and is particularly, but not exclusively, directed at a waveguide structure suitable as an optical biosensor. Background technique [0002] Recently, with the increasing prevalence of antibiotic-resistant bacteria and the increasing risk of biological warfare and bioterrorism, the need for rapid and efficient judgment of the emergence of pathogens has increased in both civilian and military applications. Since light sensors can monitor the environment in real time based on changes in optical properties associated with biological samples, the use of light sensors for pathogen detection is a better approach. [0003] Optical sensors are generally based on a stacked optical waveguide structure in which an evanescent wave associated with an optical mode present in the structure extends into a sensing layer comprising a biological sample. For example, a change in the refractive index of the sample cause...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/00G01N15/14G01N21/47G01N21/77G02B6/12G02B6/122
CPCG01N21/648G01N2021/7723G01N2015/1447G01N2021/7776G02B6/122G02B2006/12138G01N2015/0088G01N21/7703G01N21/47G01N2015/019
Inventor 穆罕默德·佐勒卜斯特凡·莫尔伯纳德·詹姆斯·特雷韦斯-布朗彼得·罗伯特·菲尔登尼古拉斯·约翰·戈达德
Owner THE SEC OF STATE FOR DEFENCE IN HER BRITANNIC MAJESTYS GOVERNMENT OF THE UK OF GREAT BRITAIN & NORTHERN IRELAND