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Organic extract for Japonicum Thunb and application thereof

A technology of water bayberry and extract, which is applied in the direction of medical preparations containing active ingredients, drug combinations, plant raw materials, etc.

Inactive Publication Date: 2005-12-14
LEAD BILLION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To date, no agent or factor has been reported on the market or under investigation that induces complete healing of severely damaged skeletal muscle

Method used

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  • Organic extract for Japonicum Thunb and application thereof
  • Organic extract for Japonicum Thunb and application thereof
  • Organic extract for Japonicum Thunb and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation of "EGJV"

Embodiment 2

[0035] Evaluation of the Dual Effects of the Active Ingredient on the Rabbit Muscle Injury Model

[0036] Here, the inventors tested the effect of the "EGJV". The test results surprisingly confirmed that the EGJV had a marked effect on the healing process of severely damaged skeletal muscle, in which regenerated muscle fibers appeared in the damaged area, compared to the control fibrous scar tissue. The EGJV has been shown to be very beneficial in stimulating angiogenesis and muscle regeneration in the early stages of the healing process of damaged muscles, and in inhibiting the formation of fibrous scars in the healing of skeletal muscle and skin lesions.

[0037] The EGJV was used in a rabbit animal model of severe muscle injury (female, N=12, average body weight: 2.5 kg). Stretch-induced muscle injury was induced by transection with surgical scissors on the rabbit tibialis anterior muscle. Immediately after the stretch-induced injury, 6 rabbits were subcutaneously injecte...

Embodiment 3

[0040] Evaluation of the Dual Effects of Active Ingredient in Rat Muscle Injury Model

[0041] EGJV was further studied in a rat skeletal muscle injury model. The experimental results confirmed that the EGJV can significantly stimulate the regeneration of blood vessels (within 24 hours) and the proliferation of satellite cells at the injured site of severely damaged muscles. Within 2 weeks of injury, the injured site was completely replaced by newly regenerated muscle fibers in EGJV-treated animals, in stark contrast fibrosis was the dominant feature in control animals.

[0042] Stretch-induced muscle damage was induced on the tibialis anterior muscle of experimental rats (SD rats, female, N=40, average body weight: 150 g) by transection with surgical scissors. Immediately after the stretch-induced injury, 20 rats were subcutaneously injected with 0.1 ml of EGJV in 5% DMSO into the tibialis anterior muscle. The other 20 rats were injected with the same volume of 5% DMSO solu...

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PUM

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Abstract

An organic extract of a Chinese herbal medicine Geum Japonicum thunb var. has been identified that displayed potent stimulatory effects on rapid agiogenesis (<24h), myogenesis and blocking fibrosis in traumatized skeletal muscles. The extract has displayed potent dual effects on angiogenesis and myogenesis in damaged skeletal muscles leading to complete skeletal muscle healing in rabbit and rat animal models. The extract of the present invention can be developed into an effective therapeutic drug for the treatment of skeletal muscle trauma, soft tissue healing including burn, skin wound and operation cut, and bone fracture and defect healings.

Description

technical field [0001] The present invention relates to Chinese herbal medicine. In particular, the present invention relates to an organic extract of Geum Japonicum Thunb variant (hereinafter referred to as "EGJV") and its use in stimulating damaged skeletal muscle and soft tissues including skin Angiogenesis, skeletal muscle regeneration, and inhibition of fibrosis. The present invention also relates to methods for preparing EGJV organic extracts, and for treating skeletal muscle damage or skin damage, promoting healing of surgical incisions, or reducing scars formed during skin healing and plastic surgery. Background technique [0002] Myrica is a genus comprising 65 species of herbaceous and subshrub plants with rhizomes having simple or pinnately compound leaves and regular flowers, such as G. borisii, G. chiloense, G. coccineum, G. macrophyllum, G.montanum (buy hemp vine), G.reptans, G.rivale, G.triflorum, G.Urbanum and G.Japonicum (soft plumeria), etc. Plumeria pub...

Claims

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Application Information

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IPC IPC(8): A61K36/00A61K36/73A61P17/02A61P21/00
CPCA61K36/73A61P17/02A61P19/08A61P21/00
Inventor 李明沈祖尧梁秉中董辉陈启明
Owner LEAD BILLION
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