Preparation of anti-infection CpG oligonucleotide DNA preparation and its application technology

An oligonucleotide and anti-infection technology, which is applied in the direction of anti-infective drugs, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as low efficiency
CN1720922AInactive Publication Date: 2006-01-18SICHUAN UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SICHUAN UNIV
Publication Date
2006-01-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a fragment of CpG oligodeoxynucleotides sequence capable of stimulating proliferation activities of animal immunologic cells, and a method for packaging this fragment of CpG oligodeoxynucleotides to prepare anti-infection DNA nano granular formulation, the use of the CpG nano particles as novel anti-infection molecular immune enhancement agent is also disclosed. The method comprises packaging CpG oligodeoxynucleotides with chitosan nano particles, immunizing experimental animals with the prepared DNA nano granular formulation separately or synergically through intramuscular injection or oral administration, finally detecting the cell and body fluid immunity indexes of the experimental animal.
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Description

technical field

[0001] 1. Biotechnology 2. Molecular Immunology Background technique

[0002] In the 21st century, human health problems have become increasingly prominent. While antibiotics and other chemical drugs are used to effectively treat infectious diseases, many drug-induced diseases and bacterial resistance to antibiotics have also emerged. At present, due to the excessive reliance on antibiotics to control infectious diseases, the problem of bacterial resistance has resulted. In the past decade or so, the multi-drug resistance and all-drug resistance of bacteria to antibiotics has spread and intensified, making many infectious diseases difficult to control. For example, infectious diseases caused by Mycobacterium tuberculosis and Escherichia coli 0157 have made a comeback, seriously threatening human life and health. At present, there is an urgent need to develop new anti-infection technology and drugs, effectively enhance the body's immune and anti-infection abi...

Claims

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