Chimpanzee trace amine associated receptors

Abstract

The present invention provides a fingerprint sequence which is specific and selective for chimp trace amine associated receptors (TAAR) forming a subfamily of G protein coupled receptors. The invention also provides the novel chimp polypeptides identified as members of this family, nucleic acids encoding said polypeptides, and vectors and host cells comprising the novel family members. In addition, the invention provides methods of identifying chimp TAARs.

Description

technical field [0001] The present invention provides fingerprint sequences specific and selective for chimpanzee trace amine-associated receptors (TAARs) forming a subfamily of G protein-coupled receptors. The present invention also provides polypeptides identified as belonging to the family members, nucleic acids encoding said polypeptides, and vectors, host cells and non-human animals containing the new family members. Background technique [0002] Trace amines (TA) are endogenous compounds structurally related to biogenic ammonia that are found in trace amounts in the mammalian nervous system. Trace amines are stored at nerve endings and are released along with classical biogenic ammonia. So far no evidence of the existence of synapses using it as the sole transmitter has been found. Recently, Borowski et al. (Trace amines: identification of a family of mammalian Gprotein_coupled receptors. Proc Natl Acad Sci USA (2001) 98 (16): 8966-71) and Bunzow et al. (Amphetamine,...

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Problems solved by technology

However, a survey of literature and public database entries revealed conflicting nomenclature for trace amine receptors, such as the human receptor GPR102 (Lee et al., Discovery and mapping of ten novel G protein-coupled receptor genes. Gene. 2001, 275(1) : 83-91.) Also known as TA5 (Borowski et al. Trace amines: identification of family of mammalian G protein-coupled receptors.Pro Natl Acad Sci USA (2001) 98(16): 8966-71), while human 5- HT4ψ (Liu et al., A serotonin-4 receptor-like pseudogene in humans. Brain Res Mol Brain Res. 1998, 53(1-2): 98-103.) was also named TA2ψ (Borowski et al., Trace amines: identification of a family of mammalian G protein-coupled receptors.Pro Natl Acad Sci USA(2001)98(16):8966-71)

In addition, GPR57 (Lee et al., Cloning and chatacterization of additional members of the G protein-coupled receptor family. Biochim Biophys Acta. 2000, 1490 (3): 311-23.), GPR58 (Lee et al., Cloning and chatacterization of additional members of the G protein-coupled receptorfamily.Biochim Biophys Acta.2000,1490(3):311-23.) and PNR (Zeng et al., Cloning of a putative human neurotransmitter receptor expressed inskeletal muscle and brain.Biochem Biophys Res Commun.1998,242(3 ):575-8.) has not been generally recognized as a trace amine receptor so far either

Such inconsistencies cause confusion and uncertainty

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