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Application of ganciclovir in preparation of medicine for treating tumor

The technology of a tumor drug, ganciclovir, is applied in the direction of anti-tumor drugs, drug combinations, active ingredients of heterocyclic compounds, etc., and can solve problems such as unsatisfactory tumor treatment

Inactive Publication Date: 2006-02-15
湖北科益药业股份有限公司
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem is that the treatment of tumors, especially liver cancer, lung cancer, and pancreatic cancer, with the above-mentioned gene constructs alone is still not ideal.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] Inhibitory effect of ganciclovir combined with ADV-TK on the growth of mouse melanoma B16.

[0016] Tumor-bearing animals with good tumor growth and good general condition were selected, and sacrificed by cervical dislocation. The tumor mass was taken out under aseptic conditions, weighed, filtered through gauze, the tumor fluid was diluted 10:1 with normal saline, and 0.2ml was inoculated under the armpit of each mouse.

[0017] The next day, the animals were randomly divided into 10 groups. Negative, positive and different administration groups were set up. The tumors in the negative control group grew spontaneously, and the positive control group was intraperitoneally injected with cyclophosphamide 100 mg / kg once. The administration group was treated with 6.7×10 8 Virus particles / kg, 2×10 9 Virus particles / kg, 6×10 9 Three doses of viral particles / kg were injected locally with ADV-TK once at the tumor inoculation site. From the third day of the test, animals we...

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Abstract

The invention relates to a novel use of Ganciclovir, especially the use of Ganciclovir and recombinant adenovirus-thymine deoxyriboside kinase construct in preparing medicament for treating tumors, including melanin tumor, neuroglioma, hepatic carcinoma or lung carcinoma.

Description

technical field [0001] The present invention relates to a new application of ganciclovir. It specifically relates to the therapeutic effect of ganciclovir on tumors. Background technique [0002] Ganciclovir (GCV) is a derivative of guanosine, usually used as a broad-spectrum anti-herpes virus drug. The principle is: after GCV enters the cell, it is quickly phosphorylated by the virus-encoded protein kinase (thymidine kinase, TK) to monophosphate GCV, and then generates diphosphate and triphosphate GCV through the action of cellular kinase. GCV triphosphate exerts its antiviral effect by inhibiting viral replication by competitively inhibiting viral DNA polymerase and incorporating into viral DNA chains to block the elongation of viral DNA. [0003] At present, tumor has become one of the important diseases leading to the death of our population. According to the statistics of the Ministry of Health, in recent years, there are 2 million new cancer patients in China every ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61P35/00
Inventor 马畅吴佳
Owner 湖北科益药业股份有限公司
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