Magnetic nanometer granule containing mitocin-C and its uses
A technology of magnetic nanoparticles and mitomycin, which is applied in the direction of inorganic non-effective ingredients, polymer compound non-active ingredients, anti-tumor drugs, etc., can solve the problem of affecting the therapeutic effect, few drug molecules that can be coupled, and small specific surface area and other issues, to achieve the effect of benefiting parenteral administration, improving bioacceptability, and large specific surface area
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Embodiment 1
[0030] 1 part of mitomycin C, 15 parts of albumin, Fe 3 o 4 5.25 servings.
[0031] The encapsulation efficiency and drug loading capacity of MMC-MNP were measured by HPLC method, and the particle size of MMC-MNP was measured by Nicomp380 nanometer particle size analyzer. The measurement results are as follows:
[0032] The encapsulation rate is 90%, the drug loading is 6%, and the average particle diameter is 70 nanometers.
[0033] Mix 8 mg of magnetic nanoparticles containing mitomycin C with 2 ml of physiological saline to obtain an intravenous injection.
[0034] Preparation:
[0035] (1) Dissolve 150 mg of albumin in 0.5 ml of Fe with a weight concentration of 105 mg / ml 3 o 4 A magnetic fluid formed with water, and then 0.75ml of mitomycin C with a weight concentration of 13.3mg / ml was mixed to obtain an aqueous phase;
[0036] (2) Using an emulsifier for the water phase and the oil phase, stirring and emulsifying at a temperature of 25° C. to obtain an emulsion;...
Embodiment 2
[0046] Components and parts by weight of the product obtained are:
[0047] Mitomycin C 1 part, polylactide glycolide 10 parts, Fe 3 o 4 8 servings.
[0048] Mix 8 mg of magnetic nanoparticles containing mitomycin C with 2 ml of physiological saline to obtain an intravenous injection.
Embodiment 3
[0050] An important evaluation index of targeted preparations is the targeting of the preparation to the target site. After the administration of targeted preparations, the drug should be mainly concentrated in the target site, and the blood is only used as a place for drug transport and exchange, and its drug concentration should be far lower than the drug concentration in the target area. In this sense, the hemodynamic changes of the drug have no It cannot fully reflect the action process of the drug in the body. Nevertheless, due to the organic connection between the target organ and the blood, there must be a certain relationship between the drug concentration in the target organ and the blood drug concentration.
[0051] Therefore this part takes the MMC-MNP (without adding magnetic field) of embodiment 1 and two groups of MMC solutions as contrast, utilizes high-performance liquid chromatography to measure the content of medicine, has studied MMC-MNP (adding magnetic fie...
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