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Microsphere injection for treating ophthalmopathy

A technology for injections and microspheres, applied in sensory diseases, nervous system diseases, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2006-09-27
段亚东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] So far, there are no publications describing microsphere injections with musk, citicoline, and traditional Chinese medicine vasodilators as the active ingredients of the drug. Therefore, it is necessary to develop and invent a microsphere injection for the treatment of diseases such as retinal degeneration and optic atrophy.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Prescription: (based on 1000 doses)

[0054] Muscone 60g

[0055] Polylactic acid 300g

[0056] Mannitol 100g

[0057] Dextran 120g

[0058] Sodium chloride 10g

[0059] Tween-80 8g

[0060] Preparation: preparation equipment: electronic constant speed mixer, ultrasonic oscillator, freeze dryer. Dissolve muskone and polylactic acid in dichloromethane solution, stir to dissolve completely, and form an organic phase. Prepare a 0.5% polyvinyl alcohol solution to form an aqueous phase. The organic phase is injected into the water phase, the stirring speed is adjusted to 400 rpm, the methylene chloride is evaporated to remove all the methylene chloride, the microspheres are separated by centrifugation, washed and dried to obtain the drug-loaded microspheres. Dissolve mannitol, dextran, sodium chloride, and Tween-80 with water for injection, adjust the pH to 6.5 with sodium dihydrogen phosphate, add drug-loaded microspheres, stir evenly, fill into bottles, freeze quick...

Embodiment 2

[0062] Prescription: (1000 dosimeters)

[0063] Citicoline 500g

[0064] Inosine 250g

[0065] Polylactic acid 800g

[0066] Mannitol 120g

[0067] Dextran 140g

[0068] Sodium chloride 10g

[0069] Tween-80 10g

[0070]Preparation: Dissolve citicoline, inosine and polylactic acid in dichloromethane solution, stir at 8000 rpm for 30 seconds to dissolve completely and form an organic phase. Inject the organic phase into 1% polyvinyl alcohol solution, stir at 300 rpm, evaporate at 25°C for 12 hours, centrifuge to pour off the supernatant, precipitate, rinse the precipitate with distilled water, dry under reduced pressure at room temperature, and collect the drug microspheres. Dilute mannitol, dextran, sodium chloride, and Tween-80 with water for injection, adjust the pH with sodium dihydrogen phosphate to form a suspension, add drug-loaded microspheres to the suspension, stir evenly, and fill it into bottle, quickly frozen, and freeze-dried to reduce the moisture content...

Embodiment 3

[0072] Prescription: (based on 1000 doses)

[0073] Anisodine 6g

[0074] Polylactic acid 30g

[0075] Mannitol 100g

[0076] Dextran 120g

[0077] Sodium chloride 10g

[0078] Tween-80 8g

[0079] Preparation: its implementation steps are the same as in Example 3.

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Abstract

The microballoon injection for treating eye diseases has medicine containing microballoons comprising medicine and microballoon forming material. The medicine is musk, citicoline and Chinese medicine vasodilator or their composition; and the microballoon forming material consists of medicinal polymer material. The microballoon injection may be used in treating several kinds of eye disease, as well as central nerve disease, cardiac vascular diseases, local nerve functional disorder and damage, and ischemic diseases. The present invention has the preferable embodiment of preparing microballoon injection or microballoon powder for injection through an optimized emulsifying-solvent volatilizing process and freeze drying process.

Description

technical field [0001] The invention belongs to pharmaceutical preparations, in particular to a biodegradable slow-release long-acting microsphere injection for treating eye diseases, more specifically to a microsphere freeze-dried powder injection or microsphere suspension injection. Background technique [0002] Retinal degeneration and optic atrophy are chronic blinding eye diseases that require long-term or life-long drug treatment. Topical eye drops, painted eyes, oral, intramuscular injection or intravenous injection, it is difficult to make the drug achieve effective drug concentration in the retina and optic nerve. The eye implant invented by the inventor (Chinese invention patent number: 01122761.3; application number: 2004100110807; application number: 2004100111091) provides a new treatment approach and new product for the treatment of such eye diseases, but this implant The agent requires surgical implantation. Retrobulbar injection can increase the drug concen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/55A61K45/06A61K9/16A61K9/14A61K9/10A61P27/02A61P25/02
Inventor 段亚东
Owner 段亚东
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