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Use of AR-A014418 in preparing medicine for preventing and treating nerve degenerative diseases

A neurodegenerative and drug technology, applied in nervous system diseases, drug combinations, pharmaceutical formulations, etc., can solve the problems of unable to prevent neuron loss, uncontrollable disease development, etc., to prevent neuron apoptosis, achieve significant curative effect, inhibit active effect

Inactive Publication Date: 2006-10-11
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, likewise, since the loss of neurons cannot be prevented, the progression of the disease cannot be controlled

Method used

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  • Use of AR-A014418 in preparing medicine for preventing and treating nerve degenerative diseases
  • Use of AR-A014418 in preparing medicine for preventing and treating nerve degenerative diseases
  • Use of AR-A014418 in preparing medicine for preventing and treating nerve degenerative diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0123] The preparation of embodiment one injection

[0124] Weigh 10 grams of AR-A014418, dissolve it in 1000 milliliters of water for injection, dissolve it, and filter it with an ultra-microfiltration membrane to prepare an injection solution with a concentration of 1 gram / 100 milliliters (1%), sterilize and dispense.

[0125] For patients with Parkinson's disease and senile dementia: the dosages for subcutaneous injection, intramuscular injection, and slow intravenous injection are all the same, 50-100 mg each time, 2-3 times a day.

Embodiment 2

[0126] The preparation of embodiment two tablet

[0127] Composition: AR-A014418 20g

[0128] Starch 6g

[0129] Citric acid 0.2g

[0130] 10% starch slurry appropriate amount

[0131] 1% magnesium stearate appropriate amount

[0132] 0.2 g of citrate was dissolved in 20 ml of 10% starch slurry. Take the proportioning amount of AR-A014418 and starch, mix evenly, add an appropriate amount of 10% starch slurry containing citric acid to make soft material, pass through a 16-mesh sieve to granulate, dry the wet granules at 40-60°C; granulate with a 16-mesh sieve, After adding an appropriate amount of 1% magnesium stearate, it is compressed to form tablets each containing 100 mg of AR-A014418.

[0133] For patients with Parkinson's disease and Alzheimer's disease: take 0.5-1.0 g orally once a day, and give it in 2-4 times.

Embodiment 3

[0134] The preparation of embodiment three sustained-release capsules

[0135] Composition: AR-A014418 10g

[0136] Calcium hydrogen phosphate 10g

[0137] HPMC4000cp 2g

[0138] HPMC100cp 2g

[0139] EC100cp 0.5g

[0140] Magnesium stearate 0.25g

[0141] Talc powder 0.25g

[0142]The composition and weight percentage contained in the capsule are: AR-A01441840%, calcium hydrogen phosphate 40%, HPMC-4000cp 8%, HPMC100cp 8%, EC100cp 2%, magnesium stearate 1%, talcum powder 1%. The preparation method is as follows: pass the proportioning amount of AR-A014418, calcium hydrogen phosphate, HPMC4000cp, HPMC 100cp and EC 100cp through a sieve of 60 mesh to 100 mesh respectively, put it in a mixer and mix it evenly, and add alcohol with a concentration of 50% to 75% as a moisturizer. Wet agent and stirred to make soft material, pass through 14 mesh to 20 mesh sieve to granulate, dry the granules at 50°C to 60°C, granulate with 14 mesh to 20 mesh sieve, then add magnesium s...

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Abstract

The invention relates to the use of AR-AO14418 in preparing medicament for preventing and treating nerve retrogression diseases, wherein the medicament comprises AR-AO14418 and medically acceptable auxiliary materials, wherein the AR-AO14418 can be bonded with the ATP bonding points of the GSK-3 beta, inhibiting GSK-3 beta activity, and preventing hepatocyte nerve.

Description

Technical field: [0001] The invention relates to a medicine for preventing and treating neurodegenerative diseases, in particular to the application of AR-A014418 in the preparation of medicines for preventing and treating neurodegenerative diseases. Background technique: [0002] Neurodegenerative diseases refer to a series of diseases caused by the degenerative changes of neurons in the human body. They mainly occur in the elderly and greatly affect people's quality of life. Among them, Parkinson's disease (PD) and Alzheimer's disease (AD) are the two most common neurodegenerative diseases. Neuron loss due to neuron apoptosis is the main pathological feature of neurodegenerative diseases, but for a long time, due to the lack of clear drug targets, people can only use "palliative" methods to treat such diseases. Specific chemicals are taken or injected intravenously to replenish the depleted neurons in the patient's brain. For example, the signs and symptoms of PD can be ...

Claims

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Application Information

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IPC IPC(8): A61K31/426A61P25/16A61P25/28
Inventor 王文雅
Owner SOUTHERN MEDICAL UNIVERSITY
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