Process for refinement and purification of fungus polysaccharide

A fungal polysaccharide and refining technology, applied in the direction of fungi, fermentation, etc., to achieve good effect, increased permeability, and low energy consumption

Inactive Publication Date: 2006-10-11
刘桢鋆
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to optimize or update the extraction process of fungal polysaccharides, starting from the molecular weight effect and molecular structure effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Embodiment 1: A, prepare a certain amount of Agaricus blazei sporocarps to dry and pulverize through a 60-100 mesh sieve; B, add pure water of 10 times the weight to the fungus sporocarps after the pulverization and sieve to mix into liquid and heat up, at 65 In the temperature range of ℃, use ultrasonic waves of 600W. to extract the fungal fruit bodies for 4 minutes, so that the polysaccharides can ooze out; C, directly remove the protein from the above-mentioned ultrasonically treated liquid, that is, remove the protein; D, use 0.18um The peptide membrane pre-filters the protein-removed liquid to remove impurities with a diameter of more than 0.18um; E, using ultrafiltration technology to purify and refine polysaccharide solution products with different components using filter membrane modules with different pore sizes, the ultrafiltration The ultrafiltration membrane used in the technology is specifically a polyvinylidene fluoride hollow fiber ultrafiltration membrane...

Embodiment 2

[0008] Example 2: A. Prepare a certain amount of Ganoderma lucidum fruiting body, dry and grind it through a 60-100 mesh sieve; B. Mix the fungal fruiting body after crushing and sieving with 30 times the weight of pure water to form a liquid and heat it up at 90°C Use 600W. ultrasonic wave to carry out 10min ultrasonic leaching treatment on the fungal fruit body, and then keep the temperature for 30min, so that the polysaccharide can fully ooze out; C. Deproteinize the above-mentioned ultrasonically treated liquid, that is, remove protein; D. Use a 0.18um peptide membrane to pre-filter the protein-removed liquid to remove impurities with a diameter above 0.18um; E. Use ultrafiltration technology to purify and refine polysaccharide solution products with different components using filter membrane modules with different pore sizes. The ultrafiltration membrane used in the ultrafiltration technology is specifically a polyvinylidene fluoride hollow fiber ultrafiltration membrane, ...

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PUM

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Abstract

This invention belonging to pre-extraction of fungus polysaccharide on pharmacy is the method to purify fungus polysaccharide with supersonic wave and hyperfiltration. The procedure is as followings: dry fungus fruiting body, leach with supersonic wave, get rid of protein, prefilter, hyperfilter to obtain different constituents and make them various products. This invention optimizes and updates fungus polysaccharide extraction method, identify kinds of fungus polysaccharides according to their effective molecular weight and molecular configuration, and achieve the goal the previous methods have never done.

Description

technical field [0001] The invention belongs to the technical process of pre-pharmaceutical refinement of fungal polysaccharides, specifically the process of realizing the refinement and purification of fungal polysaccharides by adopting ultrasonic wave and ultrafiltration technology. Background technique [0002] At present, the polysaccharide extraction process generally adopts water bath, enzyme extraction, chromatography, rectification, recrystallization and other processes. The disadvantages are: 1. The process is cumbersome, and the temperature and time requirements are specific. Two, there is no purification of effective components or the purification of components cannot be achieved during production. Most of the products are made of heteropolysaccharides. There are many invalid dross components in the products and the effective efficacy is low, which limits its development and use in pharmaceuticals. use. Three, the cost of the existing process is high, the effect ...

Claims

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Application Information

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IPC IPC(8): C08B37/00C12P19/04C12N1/14
Inventor 刘桢鋆赵晓秀赵彦臣
Owner 刘桢鋆
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