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Capillary artemisia dripping pill and its prepn process

A technology of dripping pills and preparations, applied in the field of Zangyinchen dripping pills and its preparation technology

Pending Publication Date: 2006-10-18
青海普兰特药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Various oral solid preparations developed by Zangyinchen with single or compound preparations have applied for patents and formed industrialized products [2，3] (2. Ding Jingye, etc., Extraction process, equipment and production method of Tibetan capillary active ingredients, 1992, Chinese patent application number 92108869, 3, Qinghai Provincial Department of Health, Qinghai Provincial Drug Standards, 1992, 65-67) its curative effect It has been proven by a large number of clinical trials that if the drop pill dosage form is introduced, it can not only be taken sublingually, but also can improve the rapid release and bioavailability of the main medicinal ingredients in the Zangyin Chen preparation. [4] (4 Dong Fangyan etc., new technology of modern practical traditional Chinese medicine formulation, 2001, People's Medical Publishing House, 193-202), but the solid dripping pill dosage form of raw material is owing to relate to dropping pill preparation technology, especially the formula of dropping pill dosage form And molding process and other restrictions, so far has not yet formed the formal production and use of large-scale products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] 1. Preparation of Zangyinchen Extract

[0014] Crush Zangyinchen into a coarse powder, add 8 times the amount of 85% ethanol, heat and reflux for extraction 3 times, each time for 3 hours. Filtrate, combine the filtrates, concentrate under reduced pressure to a relative density of 1.18-1.20 (60°C), and vacuum-dry to form a thick paste, which is the extract of Zangyinchen.

[0015] 2. Preparation schemes of different prescription ratios

[0016] Option 1: 100g of the extract of Zangyinchen, 200g of polyethylene glycol 4000, after the polyethylene glycol 4000 is heated until it is completely melted, add the extract of Zangyinchen, stir evenly and quickly transfer it to the storage bottle, seal it and keep it warm in the At 85°C, drip into liquid paraffin from a dropping pill machine under heat preservation conditions, and condense and solidify into pellets. Drain the formed dropping pills, wipe off the liquid paraffin, and dry at low temperature.

[0017] Scheme 2: 100...

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Abstract

The present invention relates to capillary artemisia dripping pill for treating acute hepatitis, chronic hepatitis, hepatitis B, chronic cholecystitis and other diseases and its preparation process. The present invention includes the recipe and preparation process of capillary artemisia dripping pill and the extracting process of capillary artemisia extract. The capillary artemisia dripping pill is or is not coated.

Description

[0001] the field [0002] The invention relates to a prescription of a Tibetan medicine drop pill dosage form and a preparation process thereof, that is, to a kind of medicine which has the functions of clearing away heat and detoxification, soothing the liver and promoting gallbladder, and reducing jaundice. Zangyinchen dripping pill preparation and its preparation process for clinically treating acute hepatitis, chronic hepatitis, hepatitis B, chronic cholecystitis and other diseases. Background technique [0003] Tibetan Yinchen is a traditional medicinal material used in Tibetan medicine to treat various diseases such as hepatitis, cholecystitis, liver injury, liver fibrosis, and fatty liver. It belongs to the Gentianaceae Swertia plant. A large amount of research data shows that the known chemical components in this type of plant are triterpenoids mainly composed of oleanolic acid, picrosides mainly composed of swertiamarin, swertiaroside and gentiopicroside, The main fl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/51A61K9/20A61P1/16A61P31/14
Inventor 孙洪发
Owner 青海普兰特药业有限公司
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