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Use of levo morpholine nidazole for preparing medicine for antiparasitic infection

An anti-parasitic infection, morphinidazole technology, applied in anti-infective drugs, drug combinations, pharmaceutical formulations, etc.

Active Publication Date: 2006-10-25
NANJING SANHOME PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Levomorphinidazole has no related reports

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1. preparation levomorphinidazole tablet

[0052] Prescription composition:

[0053] Levomorphinidazole 100mg / tablet

[0054] Pregelatinized starch 100mg / tablet

[0055] Microcrystalline Cellulose 40mg / tablet

[0056] Starch 50mg / tablet

[0057] Sodium Carboxymethyl Starch 5mg / tablet

[0058] Magnesium stearate 5mg / tablet

[0059] Proper amount of povidone aqueous solution (6%)

[0060] Preparation process: Taking the preparation of 1000 Levomorphinidazole tablets as an example, the specific preparation method is to pass the main drug and auxiliary materials through a 100-mesh sieve respectively, and weigh the prescribed amount of Levomorphinidazole, pregelatinized starch, Mix microcrystalline cellulose, starch and carboxymethyl starch sodium evenly, use 6% povidone aqueous solution to make soft material, make wet granules with 20 mesh sieve, dry at 40°C, granulate with 18 mesh sieve, add to the granules The prescribed amount of magnesium stearate is m...

Embodiment 2

[0061] Embodiment 2. preparation levomorphinidazole capsule preparation

[0062] Prescription composition:

[0063] Levomorphinidazole hydrochloride 300mg / tablet

[0064] Starch 45mg / tablet

[0065] Magnesium stearate 5mg / tablet

[0066] 6% starch slurry appropriate amount

[0067] Preparation process: pass the raw and auxiliary materials through a 100-mesh sieve. Take by weighing the L-morpholinidazole hydrochloride of recipe quantity, starch, mix uniformly, make soft material with 6% starch slurry, granulate with 22 mesh sieves, dry in 40 ℃, granulate with 20 mesh. Add the prescribed amount of magnesium stearate, mix well, and fill the granules into No. 1 capsules, each about 350mg.

Embodiment 3

[0068] Example 3. Preparation of Levomorphinidazole Granules

[0069] Prescription composition:

[0070] Levomorphinidazole 300mg / bag

[0071] Sucrose 400mg / bag

[0072] Microcrystalline cellulose 150mg / bag

[0073] Starch 150mg / bag

[0074] 6% starch slurry appropriate amount

[0075] Preparation process: pass the raw and auxiliary materials through a 100-mesh sieve. Take by weighing L-morphonidazole, sucrose, microcrystalline cellulose, starch of prescription quantity, mix uniformly, make soft material with 6% starch slurry, granulate with 16 mesh sieves, dry in 40 ℃, granulate with 14 mesh. Use a 40-mesh sieve to remove fine powder, and pack in 1g per bag.

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PUM

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Abstract

The present invention provides an application of levomorpholinonidazol [R-(-)-1-(2-methyl-5nitroimidazole-1-group)-morpholinylpropane-2-alcohol] or its medicinal salt in preparation of medicine for resisting amoebic infection and resisting vaginal trichomonad infection.

Description

technical field [0001] The present invention relates to L-morpholinidazole [R-(-)-1-(2-methyl-5-nitroimidazol-1-yl)-3-morpholinopropan-2-ol] or its medicinal salt The new application of the invention is the application in the preparation of anti-parasitic infection drugs. Background technique [0002] Levomorphinidazole is R-(-)-1-(2-methyl-5-nitroimidazol-1-yl)-3-morpholinopropan-2-ol. 2-Methyl-5-nitazole imidazole derivatives have good anti-anaerobe activity, and many preparation methods have been disclosed. The Chinese patent application whose publication number is CN1605586A discloses α-substituted 2-methyl-5-nitroimidazole-1-ethanol derivatives and their preparation methods and uses, but for α-substituted 2-methyl-5- The optical activity of the nitroimidazole-1-ethanol derivatives has not been elucidated. Levomorphinidazole has no relevant reports at present. Contents of the invention [0003] The object of the present invention is to provide L-morpholinidazole [R...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5377A61P33/00
Inventor 张仓陶小鑫滕再进
Owner NANJING SANHOME PHARMACEUTICAL CO LTD
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