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Non-toxic ion liquid its production and use

A technology of ionic liquids and anions, which is applied in the fields of pharmaceutical formulations, medical preparations of non-active ingredients, organic chemistry, etc., can solve problems such as the solubility of insoluble drugs, limited types of co-solvents, complex preparation processes, etc., and achieve thermal Good stability, low cost and simple preparation process

Inactive Publication Date: 2006-11-01
HEBEI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some of these additives have side effects on the human body
At the same time, due to the limited types of surfactants and co-solvents, the preparation process is complicated and the cost is high
And it cannot solve the solubility problem of all poorly soluble drugs in water

Method used

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  • Non-toxic ion liquid its production and use
  • Non-toxic ion liquid its production and use
  • Non-toxic ion liquid its production and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of L-lactate choline ionic liquid

[0028] Synthesis according to the synthesis method of ionic liquid 1: in 32 ml of 45% methanol solution of choline hydroxide, 9.6 ml of 90% L-lactic acid solution was added dropwise. After stirring for 0.5 hour, after purification, the solvent was evaporated to dryness under high vacuum at 45°C to obtain 22.0 g of a colorless L-lactate choline ionic liquid.

Embodiment 2

[0030] Preparation of DL-lactatecholine ionic liquid

[0031] According to the synthesis method 1 of ionic liquid, 11.0 ml of 80% DL-lactic acid solution was added dropwise to 32 ml of choline hydroxide 45% methanol solution. After stirring for 0.5 hours, after purification, the solvent was evaporated to dryness under high vacuum at 45°C to obtain 22.3 g of a colorless DL-lactatecholine ionic liquid.

Embodiment 3

[0033] Preparation of Choline Isobutyrate Ionic Liquid

[0034] Synthesis according to the synthesis method of ionic liquid 1: in 20 ml of 45% methanol solution of choline hydroxide, 6.14 g of isobutyric acid was added dropwise. After stirring for 0.5 hour, after purification, the solvent was evaporated to dryness under high vacuum at 45°C to obtain 15.4 g of colorless choline isobutyrate ionic liquid.

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Abstract

A non-toxic ionic liquid, its production and use are disclosed. In the molecular formula, cation is quaternary cationics. R1, R2, R3 and R4 can be H, different or indifferent alkyl of C1-C8 or contain hydroxyl or carboxylic derivatives. It can make various medicine insoluble into solution or micro-emulsion with different concentration. It can be used fro solvent, fusing agent or surface active agent. It has better melting degree and biological utilization.

Description

technical field [0001] The invention belongs to the synthesis of new ionic liquid in the field of chemical materials and manufacturing and its application in medicine and pesticide as a new solvent, co-solvent or surfactant. Background technique [0002] Ionic Liquids (Ionic Liquids) refer to positive ions such as organic alkylimidazoles, quaternary ammonium salts, alkylpyridines and different negative ions such as chloride ions, BF 4 - , PF 6 - , CF 3 CO 2 - , N(CN) - 2 Many of them are liquid at room temperature or even at low temperature, so they are also called room temperature ionic liquids. They have no vapor pressure, good thermal stability (up to 300-400°C), good electrical conductivity; for organic compounds, inorganic compounds, metal organic compounds, gases such as: H 2 , CO, O 2 It has a wide range of solubility; it can also be miscible with organic solvents, water, or insoluble to form a two-phase or multi-phase reaction system; the most notable is it...

Claims

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Application Information

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IPC IPC(8): C07C211/62A61K47/18C07C215/00C07C229/00
Inventor 刘庆彬张占辉张福军
Owner HEBEI NORMAL UNIV