Anti-IGF-I receptor antibody

An antibody and receptor technology, applied in the direction of antibodies, antibody medical components, anti-receptor/cell surface antigen/cell surface determinant immunoglobulin, etc.
CN1886424AInactive Publication Date: 2006-12-27IMMUNOGEN INC
26 Cites 4 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
IMMUNOGEN INC
Publication Date
2006-12-27
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

Antibodies, humanized antibodies, resurfaced antibodies antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to, and inhibit, insulin-like growth factor-I receptor, antagonize the effects of IGF-I, IGF-II and serum on the growth and survival of tumor cells, and which are substantially devoid of agonist activity. The antibodies and fragments thereof may be used, optionally in conjunction with other therapeutic agents, in the treatment of tumors that express elevated levels of IGF-I receptor, such as breast cancer, colon cancer, lung cancer, ovarian carcinoma, synovial sarcoma, prostate cancer and pancreatic cancer and the derivatized antibodies may be used in the diagnosis and imaging of tumors that express elevated levels of IGF-I receptor.
Need to check novelty before this filing date? Find Prior Art

Description

[0001]

[01] This application is a continuation-in-part of parent application 10 / 170,390, filed June 14, 2002, which parent application is hereby incorporated by reference in its entirety. field of invention

[0002]

[02] The present invention relates to antibodies that bind to human insulin-like growth factor-I receptor (IGF-I receptor). More specifically, the present invention relates to anti-IGF-I receptor antibodies that inhibit the cellular function of IGF-I receptor. More specifically, the invention relates to antibodies that antagonize the effects of IGF-I, IGF-II, and serum on tumor cell growth and survival, which substantially lack agonist activity. The present invention also relates to fragments of said antibodies, humanized and resurfaced forms of said antibodies, conjugates of said antibodies, derivatives of said antibodies, and their Uses in diagnostic, research and therapeutic applications. The present invention further relates to improved antibodies or fragment...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More