Biomolecule mobilization substrate, bio-chip and biological sensor
A biomolecule and biochip technology, applied in biochemical equipment and methods, microbial determination/inspection, biological testing, etc., can solve the problems of time-consuming and low efficiency, achieve long life, not easy to inactivate, and reduce time effect of change
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[0073] figure 1 It is a diagram schematically showing the structure of the biochip 11 (that is, the biomolecule-immobilized substrate 12 on which receptors are immobilized) of the present invention. In the biomolecule immobilization substrate 12 , as described in detail below, the lipid bilayer 24 is tethered on the chip substrate 21 with the metal layer 22 formed on the surface through the hydrophilic monomolecular membrane 23 . In addition, the biochip 11 immobilizes the biorecognition molecule 27 on the lipid bilayer 24 of the biomolecule immobilization substrate 12 , and the receptor 28 is immobilized on the biorecognition molecule 27 .
[0074] The chip substrate 21 is a thin plate formed of a light-transmitting material such as glass or quartz. A plurality of metal particles are fixed on the chip substrate 21 to form a metal layer 22 .
[0075] The metal particles forming the metal layer 22 are nano-level inorganic metal particles such as Au and Ag with a diameter of s...
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