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Chinese medicine injection for supplementing qi and recovering pulse and its preparing method

A technology for replenishing qi and rejuvenating pulse and injection, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc. problem, to achieve the effect of significant synergy, improved efficacy, and rapid microcirculation

Inactive Publication Date: 2007-01-24
罗益民
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In modern clinics, Shenmai Injection or Shengmai Injection is often used to treat shock, heart failure and related diseases. It has a definite curative effect on patients with mild symptoms. Clinical application has proved that Shenmai Injection and Shengmai Injection mainly achieve the purpose of improving the pathological state through the cardiotonic effect, rather than directly acting on the cardiovascular system. Therefore, the boosting process takes a long time and the effect of improving microcirculation is moderate. , which is not conducive to quickly improving the pathological state of acute and severe patients, and has obvious limitations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] (1) Prescription: Ginseng 1000g, Ophiopogon japonicus 1000g, Cornel officinalis 8000g

[0060] (2) Preparation method: take the ginseng medicinal material, and use 8 times, 6 times, and 6 times the amount of 70% ethanol to reflux extract 3 times, each time for 1 hour; recover the ethanol and concentrate it to 2g per 1ml of the medicinal material, and use Clarifying agent treatment, high-speed centrifugation, supernatant ultrafiltration (molecular weight cut-off 100000), the ultrafiltrate is concentrated into 6g of medicinal material per 1ml; the concentrated solution is extracted 3 times with 2 times the amount of water-saturated n-butanol equivalent, Recover butanol, dissolve the residue in water, pass through D101 or AB-8 macroporous adsorption resin, elute with 25% low-concentration ethanol for 3 times the column volume, discard the eluent, and then use 5 times the column volume The 80% volume of high-concentration ethanol is eluted, the high-concentration ethanol el...

Embodiment 2

[0062] (1) Prescription: Ginseng 1000g Ophiopogon japonicus 1000g Cornus officinalis 6000g

[0063](2) Preparation method: Take ginseng medicinal materials, Ophiopogon japonicus medicinal materials and Cornus officinalis medicinal materials, decoct and extract with 10 times the amount, 8 times the amount, and 8 times the amount of water respectively for 1.5 hours each time; collect the water extract and concentrate Add ethanol until the alcohol content is 70% per 1ml, and filter; recover the ethanol from the filtrate, boil, and refrigerate and stand at 0-4°C for 24 hours, centrifuge at high speed, and take the supernatant for ultrafiltration ( cut-off molecular weight 100000); the ultrafiltrate is concentrated into a liquid extract with a relative density of 1.1, extracted three times with 2 times the amount of water-saturated n-butanol in equal amounts, recovered butanol, and dissolved the residue in water, passed D101 type or AB- Type 8 macroporous adsorption resin, first el...

Embodiment 3

[0065] (1) Prescription: Ginseng 2000g, Ophiopogon japonicus 2000g, Cornus officinalis 8000g

[0066] (2) Preparation method: Take ginseng medicinal materials, Ophiopogon japonicus medicinal materials and Cornus officinalis medicinal materials, extract with 80% ethanol under reflux for 6 hours, recover ethanol and concentrate to 2 g of medicinal materials per 1 ml, treat with clarifying agent, high-speed centrifugation, and take supernatant Liquid ultrafiltration (molecular weight cut-off 100000), the ultrafiltrate is passed through D101 type or AB-8 type macroporous adsorption resin, firstly eluted with water until nearly colorless, then eluted with 75% ethanol of 6 times the column volume, collected ethanol washed Deliquid, recover ethanol, mix the residue with 3 times the amount of neutral alumina, dry, first use acetone-ether (1:1) mixed solvent to circulate back to decolorize, and then use 90% high-concentration ethanol to circulate and reflux to elute 4 hours, collect th...

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Abstract

The present invention discloses a kind of qi supplementing and pulse-recovering Chinese medicine injection and its preparation process, and belongs to the field of medicine preparing technology. The Chinese medicine injection is prepared with Chinese medicinal materials ginseng, ophiopogon root and dogwood in certain weight proportion, and through first extraction to obtain intermediate and the subsequent preparation into injection, transfused liquid or freeze dried powder for injection. The Chinese medicine injection is used in treating shock caused by different causes, multiple organ failure, coronary heart disease and other cardiac and cerebral vascular diseases, and may be also used for auxiliary treatment of cancer and diabetes.

Description

Technical field [0001] The invention belongs to the technical field of pharmacy, and relates to a traditional Chinese medicine injection for replenishing qi and rejuvenating the veins, in particular to an injection made from traditional Chinese medicine ginseng, radix radices japonicus and cornus officinalis, and also relates to a preparation method of the injection. Background technique [0002] Shock and cardiovascular and cerebrovascular diseases are common clinical critical illnesses. Shock patients show symptoms such as fainting, significant drop in blood pressure, weak pulse, cyanosis, cold limbs, sweating, palpitations, etc., which are called "juetuo" and "jueni" in traditional Chinese medicine. Modern research proves that: tissue ischemia and hypoxia in shock patients lead to cell dysfunction, and at the same time, the blood is continuously concentrated, which promotes the aggregation of red blood cells and the formation of microthrombosis. Reperfusion injury, which...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P9/00
Inventor 罗益民蔡炜
Owner 罗益民
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