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Method for preparing absorbent antiseize porous membrane

A porous membrane and anti-adhesion technology, applied in the field of spacers, can solve the problems of membrane airtightness, no exchange of nutrients, no permeability, etc., and achieve good biocompatibility, excellent permeability, and excellent attachment sexual effect

Inactive Publication Date: 2007-02-07
成都迪康中科生物医学材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it has a certain anti-adhesion effect, there are still some problems in the application. The reasons are: 1) due to the colorless and transparent, it is difficult to distinguish during the operation; 2) due to the characteristics of the polylactic acid material itself, the film is brittle and hard There will be a tingling sensation; 3) There will be no adhesion to the tissue, warping will occur, and sutures will be required; 4) The membrane is airtight and has no permeability, and the tissue under the membrane will be congested or even necrotic
no exchange of nutrients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 4.4 grams of poly DL lactic acid (molecular weight: 90,000) was dissolved in a mixed solvent of 100 ml of dioxane and 10 ml of water, and stirred until completely dissolved for use.

[0024] Put 8.5ml (or more than 8.5ml) of the above solution on a glass plate with a side length of 10cm on a horizontal operating table at an ambient temperature of 25°C. 5 hours, and then freeze-dried in a lyophilizer for 24 hours.

[0025] The film was taken out from the freeze dryer, calendered, packaged, and sterilized by gamma ray sterilization to obtain samples.

[0026] The pore diameter was determined to be 16 μm by mercury intrusion porosimetry.

Embodiment 2

[0028] Dissolve 4.4 grams of poly DL lactic acid (molecular weight: 160,000) in 100 ml of dioxane, stir until completely dissolved, and filter for use.

[0029] Put 13ml (or more than 13ml) of the above solution on a glass plate with a side length of 12cm on a horizontal operating table at an ambient temperature of 25°C, pre-freeze at -55°C for 5 hours, and then freeze-dry in a lyophilizer for 48 hours . The film was taken out from the lyophilizer, calendered, and dried in a vacuum oven at 25° C. for 3 days under vacuum.

[0030] The pore size was determined to be 92 μm by mercury intrusion porosimetry.

Embodiment 3

[0032] Poly L lactic acid (molecular weight: 80000), 4.0 grams, was dissolved in a mixed solvent of 100 ml of dioxane and 10 ml of water, stirred until completely dissolved, and filtered for use.

[0033] On a horizontal operating platform, the ambient temperature is 25°C, pour 14ml of the above solution on a glass plate with a side length of 12cm, and the rest are the same as above. Put 13ml (or more than 13ml) of the above solution on a glass plate with a side length of 12cm on a horizontal operating table at an ambient temperature of 25°C, pre-freeze at -55°C for 5 hours, and then freeze-dry in a lyophilizer for 48 hours . The film was taken out from the lyophilizer, calendered, and dried in a vacuum oven at 25° C. for 3 days under vacuum.

[0034] The pore size was determined to be 102 μm by mercury intrusion porosimetry.

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PUM

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Abstract

The invention relates to a method for preparing adsorption anti-adhere porous film, which comprises: dissolve, film, refrigerate, cool, compress, extend, pack, and disinfect, wherein the refrigerate and cool are processed in refrigerator at -85 to -15Deg. C for 2-8 hours, the processed in refrigerator for 24-96 hours, to make the anti-adhere film porous, while its appearance is white fabric film, with better penetrate property.

Description

technical field [0001] The invention relates to a spacer for preventing wound adhesion after operation, more specifically, the invention relates to a preparation method of an absorbable anti-adhesion porous membrane. Background technique [0002] The prevention of wound adhesion in surgery has always been an unresolved problem. The sequelae of postoperative tissue adhesions are: continuous pain at the surgical site, which can last for several years; partial loss of function at the surgical site, such as the inability of the limbs to move freely after tendon surgical adhesion. The main problem of silicone oil, sodium hyaluronate, chitin, etc. currently used clinically is poor anti-adhesive effect, or even no anti-adhesive effect. This is because these materials are all fluid or semi-fluid, and are absorbed quickly in the body, usually within 3-4 days, and the anti-adhesion effect is short, so it is often difficult to achieve an ideal anti-adhesion effect. [0003] It is a c...

Claims

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Application Information

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IPC IPC(8): A61L15/50A61L15/26A61L31/00C08J9/00C08J5/22
Inventor 熊成东潘高峰李晓萍
Owner 成都迪康中科生物医学材料有限公司
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