Extended release pharmaceutical compositions of divalproex sodium

A technology of divalproex sodium and slow-release drugs, applied in drug combinations, active ingredients of anhydrides/acids/halides, nervous system diseases, etc.
CN1921838AInactive Publication Date: 2007-02-28RANBAXY LAB LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
RANBAXY LAB LTD
Publication Date
2007-02-28
Estimated Expiration
Not applicable · inactive patent
Patent Text Reader

Abstract

The present invention relates to a sustained release preparation comprising valproic acid and the pharmaceutical acceptable salt, ester or amide, or divalproex sodium, and a preparation method of the sustained release preparation.
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Description

technical field

[0001] The present invention relates to sustained-release preparations comprising valproic acid, and pharmaceutically acceptable salts, esters or amides thereof or divalproex sodium (divalproex sodium) and a preparation method thereof. Background of the invention

[0002] Valproic acid, 2-valproic acid and their derivatives are widely used in the treatment of mania, migraine and epilepsy. These compounds dissociate into the valproate ion in the gastrointestinal tract.

[0003] Several physical properties of valproic acid and its derivatives make formulation into dosage forms problematic. They are liquid or liquefy rapidly and are viscous. Also by nature, most valproic acid and its derivatives are extremely hygroscopic. These physicochemical properties of valproic acid and its derivatives present serious problems in the manufacture of pharmaceutical compositions.

[0004] In addition, valproic acid and its derivatives have short elimination half-lives. Fo...

Claims

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