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Rnai agents for anti-sars coronavirus therapy

A technology of SARS virus and coronavirus, which is applied in the field of compositions for the treatment of severe acute respiratory syndrome, and can solve problems such as inadequate treatment of lung and respiratory diseases

Inactive Publication Date: 2007-02-28
INTRADIGM CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Similar to the serious challenge of respiratory infections, many lung and respiratory diseases are undertreated, including asthma and COPD

Method used

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  • Rnai agents for anti-sars coronavirus therapy
  • Rnai agents for anti-sars coronavirus therapy
  • Rnai agents for anti-sars coronavirus therapy

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Embodiment Construction

[0047] The present invention provides compositions and methods for treating coronavirus infection in mammals, especially primates and humans, by using siRNA molecules delivered in vivo to inhibit coronavirus gene expression.

[0048] More specifically, the present invention provides the inhibition of genes or genomic material in lung tissue. Provides therapeutic or preventive therapy for infectious diseases by inhibiting the genes or genomes of viruses. The present invention provides short double-stranded RNA oligonucleotides or siRNAs that inhibit gene expression with mismatched sequences or inhibit RNA viral genomes. The invention also provides nucleic acid (including RNA or DNA) therapeutics. The invention also provides methods of delivery into lung tissue. In one embodiment, the present invention provides inhibitors of coronaviruses, especially SARS coronaviruses. Inhibitors of these respiratory tract infections, including respiratory viral infections, are useful as the...

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Abstract

The present invention provides compositions and methods for treating severe acute respiratory syndrome (SARS). More specifically, the present invention describes nucleic acid substances such as siRNA molecules and analogs thereof that target respiratory tract infections (including SARS coronavirus) and their use methods for clinical treatment of SARS, respiratory virus infections, and for biodefense. needed for the prevention and treatment of respiratory infections, for the treatment of respiratory diseases, and for the development of therapeutic targets for respiratory diseases and infections.

Description

[0001] This application claims priority to Provisional Application Serial No. 60 / 465,216, filed April 25, 2003, the contents of which are incorporated herein by reference in their entirety. field of invention [0002] The present invention provides compositions and methods for treating severe acute respiratory syndrome (SARS). More specifically, the present invention describes nucleic acid substances (such as siRNA molecules) and their analogs targeting respiratory tract infections (including SARS coronavirus) and methods of use thereof, for clinical treatment of SARS and respiratory virus infections, for biological Prevention and treatment of respiratory infections required for defense, for the treatment of respiratory diseases and for the development of therapeutic targets for respiratory diseases and infections. The present invention provides treatments and methods for human lung diseases, including genetic diseases, infectious diseases, pathological con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68C07H21/04A01N43/04C12NC12N15/113
CPCC12N2310/14C12N2310/53C12N15/1131C12Q1/701A61P11/00A61P29/00A61P31/14A61P35/00
Inventor Q·Q·唐P·Y·卢F·Y·谢Y·刘J·徐M·C·沃德尔
Owner INTRADIGM CORP
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