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Method of making antitussive medicine and relieving cough

Through the development of an antitussive pharmaceutical composition of aphromonamide and p-phenylamine-type compounds, the effectiveness and side effects of existing non-specific antitussive drugs have been solved, a safer cough treatment plan has been provided, and the compound has been identified The quality of medicinal herbs realizes the scientific identification and quality control of traditional medicinal herbs.

Inactive Publication Date: 2007-03-21
HONG KONG JOCKEY CLUB INST OF CHINESE MEDICINE
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Problems solved by technology

Another problem is that there may not be sufficient raw material for the preparation of neo-metrocinine as an antitussive

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0046] Separation of Croomine and Stemoninine

[0047] Croomine and stemoninine can be easily extracted from the hundreds available in the open market. One method is described as follows: the dry root tubers of C. chinensis are cut into small cubes and extracted twice with 95% ethanol under reflux for two hours. The extracts were collected and combined, then dried under reduced pressure. The syrupy residue was dissolved with 4% hydrochloric acid and filtered. The acidic filtrate was extracted successively with ether and dichloromethane. The dichloromethane layer gave crude alkaloid fraction 1. with 35% NH 4 The acidic aqueous phase was basified to pH 9 with OH, then extracted with ether. Evaporation of ether yielded crude alkaloid fraction 2. Crude alkaloid fractions 1 and 2 were chromatographed on a silica gel column with a mixed solvent of hexane and ethyl acetate (4:6) as eluent and monitored by TLC. Part 1 gives a pulpy alkaloid identified as stemoninine (2). Fract...

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Abstract

Method for relieving cough using an effective antitussive chemical compound belonging to stemoamide or tuberostemospironine and method for manufacturing pharmaceutical compositions for treating or relieving cough in human and animal subjects which including a stemoamide or tuberostemospironine compound. In addition, the antitussive property of the compounds provides a method for assessing the quality of herbs traditionally used in treating cough by analyzing the content of the effective chemical ingredient, i.e., compounds of stemoamide type and / or tuterostemospironine type. It further provides a method for identifying medicinal herbs which may be used for relieving cough by phytochemical determination of the existence of compounds that are of stemoamide or tuterostemospironine type.

Description

technical field [0001] The present invention relates to methods for the preparation of effective antitussives and for the relief of cough in a human or animal subject. In particular, it relates to antitussive pharmaceutical compositions containing one or more stemoamide-type compounds and / or one or more tuberostemospironine-type compounds and their cough-relieving properties. application. The present invention also relates to a method for quality control of medicinal herbs traditionally used in the east for treating cough by analyzing the content of effective chemical components. The present invention further relates to a method for the identification of medicinal herbs for the relief of cough by phytochemical determination of crotonamide or the presence of phytospirulina-type compounds. Background technique [0002] Cough is one of the most common ailments seeking medical attention. It can be divided into acute and chronic cough according to its duration. The most commo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/55A61K9/08A61K9/10A61K9/20A61K9/48A61P11/14
CPCA61K31/55A61P11/14
Owner HONG KONG JOCKEY CLUB INST OF CHINESE MEDICINE
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