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Double resin process for preparing high quality active gingko leaf component extract

An active ingredient, a technology of ginkgo biloba, applied in the field of ginkgo biloba extract, can solve the problems of unstable quality of ginkgo biloba extract, affecting the curative effect of ginkgo biloba preparations, and high production costs, achieving control of quality fluctuations, easy industrial production, and taking handy effect

Active Publication Date: 2007-03-21
辽宁亿邦制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The former has high residual solvent and production cost, while the latter has high product purity and high yield
However, due to the influence of factors such as ginkgo leaf raw materials, picking time and enrichment and separation process, the quality of ginkgo leaf extracts is seriously unstable, which directly affects the curative effect of ginkgo leaf preparations.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take 50kg each of ADS-17 and ADS-F8 resins, add water and soak them for 12 hours, scoop off the small resins suspended on the surface, put them into the chromatography column by wet method (there should be no air bubbles in the middle of the resins), soak them in absolute ethanol for 24 hours , make it fully swell, and then wash with absolute ethanol until a small amount of distilled water is added to the eluate (add 4 mL of distilled water to 1 mL of washing liquid) until there is no white turbidity, and then wash the resin with distilled water until it does not contain ethanol. Then perform hydrochloric acid conversion, that is, pass through the column with distilled water with a pH of 3.5 until the pH of the effluent is 3.5.

[0019] The purchased dry green ginkgo leaves are further dried, removed and crushed at 55-65°C, passed through a 20-mesh sieve, weighed 100kg, placed in an extraction tank, added 1000L of 50% ethanol solution, and stirred under reflux at 68-72°C...

Embodiment 2

[0024] Take 50kg each of ADS-17 and ADS-F8 resins, add water and soak them for 12 hours, scoop off the small resins suspended on the surface, put them into the chromatography column by wet method (there should be no air bubbles in the middle of the resins), soak them in absolute ethanol for 24 hours , make it fully swell, and then wash with absolute ethanol until a small amount of distilled water is added to the eluate (add 4 mL of distilled water to 1 mL of washing liquid) until there is no white turbidity, and then wash the resin with distilled water until it does not contain ethanol. Then perform hydrochloric acid conversion, that is, pass through the column with distilled water with a pH of 3.5 until the pH of the effluent is 3.5.

[0025] The purchased dry green ginkgo leaves are further dried, removed and crushed at 55-65°C, passed through a 20-mesh sieve, weighed 100kg, placed in an extraction tank, added 900L of 60% ethanol solution, and stirred under reflux at 68-72°C ...

Embodiment 3

[0030] Take 50kg each of ADS-17 and ADS-F8 resins, add water and soak them for 12 hours, scoop off the small resins suspended on the surface, put them into the chromatography column by wet method (there should be no air bubbles in the middle of the resins), soak them in absolute ethanol for 24 hours , make it fully swell, and then wash with absolute ethanol until a small amount of distilled water is added to the eluate (add 4 mL of distilled water to 1 mL of washing liquid) until there is no white turbidity, and then wash the resin with distilled water until it does not contain ethanol. Then perform hydrochloric acid conversion, that is, pass through the column with distilled water with a pH of 3.5 until the pH of the effluent is 3.5.

[0031] The purchased dry green ginkgo leaves are further dried, removed and crushed at 55-65°C, passed through a 20-mesh sieve, weighed 100kg, placed in an extraction tank, added 800L of 70% ethanol solution, and stirred under reflux at 68-72°C ...

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PUM

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Abstract

The present invention relates to modern extracting and purifying process for preparing gingko leaf extract with rich active component. Compared with available process including organic solvent extraction and single resin adsorption, the modern extracting and purifying process has the advantages of reasonable technological path, high extracting rate and high effective component content in the product, and the prepared ginkgo leaf preparation has effectively controlled quality, determined curative effect and tacking convenience.

Description

technical field [0001] The invention relates to a method for preparing ginkgo leaf extract rich in active ingredients by applying the extraction and purification technology of modern natural plant medicinal ingredients. Background technique [0002] Ginkgo biloba extract mainly contains a variety of physiologically active ingredients such as flavonoids and ginkgo terpene lactones, which have good health care and therapeutic functions for the human body, especially as a treatment for cardiovascular and cerebrovascular diseases and platelet activating factor antagonists. Patients at home and abroad are welcome. [0003] my country is the hometown of Ginkgo biloba. At present, my country's Ginkgo biloba resources account for 70% of the world. Countries in Europe, America and East Asia are scrambling to import ginkgo leaves from my country to extract and separate the active ingredients and produce various preparations. The export of a large amount of ginkgo leaf resources has ...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61K127/00
Inventor 张黎明陆福平王艳
Owner 辽宁亿邦制药有限公司
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