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Preparation method of pH sensitive carboxymethyl chitosan hydrogel

A technology of carboxymethyl chitosan water and carboxymethyl chitosan, which is applied in the field of preparation of pH-sensitive dialdehyde starch cross-linked carboxymethyl chitosan hydrogel, can solve the toxic and side effects of human body, and has no pharmaceutical application value, etc. problem, to achieve good pH sensitivity and good biocompatibility

Inactive Publication Date: 2007-05-16
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since these cross-linking agents themselves are highly toxic substances, they have great toxic and side effects on the human body and have no practical pharmaceutical application value.

Method used

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  • Preparation method of pH sensitive carboxymethyl chitosan hydrogel

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The carboxymethyl substitution degree is 0.6, the viscosity average molecular weight is 3.5×10 5 Add 5.0 grams of carboxymethyl chitosan into 125 milliliters of distilled water, stir at 70° C. until all dissolve to obtain 4% (weight ratio) clear carboxymethyl chitosan aqueous solution; the degree of oxidation is 60% dialdehyde Add 10.0 grams of starch into 200 milliliters (i.e. 200 grams) of water, stir at 60° C. to make it dissolve as much as possible, and filter to obtain a 5% (by weight) dialdehyde starch aqueous solution. The above carboxymethyl chitosan aqueous solution and dialdehyde starch aqueous solution were stirred and mixed at 50°C for 5 hours according to the weight ratio of 1:0.5. After vacuum defoaming, they were transferred to a test tube and left at room temperature for 15 hours to form a gel. Then the prepared hydrogel is taken out from the test tube, fully washed with deionized water, put into a vacuum oven and dried to constant weight to obtain pH-se...

Embodiment 2

[0021] The carboxymethyl substitution degree is 0.9, the viscosity average molecular weight is 4.5×10 5 3.0 grams of carboxymethyl chitosan joins in 100 milliliters of water, stirs at 60 ℃ until dissolving completely, obtains the clarification carboxymethyl chitosan aqueous solution of 3% (weight ratio); Dialdehyde starch that oxidation degree is 66.8% 10.0 grams were added into 250 milliliters of water, stirred at 50°C to make it dissolve as much as possible, filtered to obtain 4% (by weight) dialdehyde starch aqueous solution. The above-mentioned carboxymethyl chitosan aqueous solution and dialdehyde starch aqueous solution are fully stirred and mixed evenly at 30° C. according to the ratio of 1: 1.5 (weight ratio), transferred to a test tube, vacuum defoamed, and left to stand at room temperature for 18 hours; then The prepared hydrogel was taken out from the test tube, fully washed with deionized water, and vacuum-dried to constant weight to obtain a pH-sensitive carboxyme...

Embodiment 3

[0024] The carboxymethyl substitution degree is 1.2, the viscosity average molecular weight is 5.0×10 5 1.0 gram of carboxymethyl chitosan joins in 100 milliliters of water, stirs at 40 ℃ until dissolving completely, obtains the clarification carboxymethyl chitosan aqueous solution of 1% (weight ratio); Dialdehyde starch that oxidation degree is 50% 15.0 grams were added into 250 milliliters of water, stirred at 80°C to make it dissolve as much as possible, filtered to obtain 6% (by weight) dialdehyde starch aqueous solution. The above-mentioned carboxymethyl chitosan aqueous solution and dialdehyde starch aqueous solution are fully stirred and mixed evenly at 60° C. according to the ratio of 1: 3.0 (weight ratio), transferred to a test tube, vacuum defoamed, and left standing at room temperature for 24 hours; then The prepared hydrogel was taken out from the test tube, fully washed with deionized water to remove impurities, and vacuum-dried to constant weight to obtain pH-sen...

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Abstract

The invention discloses a preparing method of pH value sensitive dialdehyde starch crosslinking carboxymethyl chitosan aquagel, which comprises the following steps: blending carboxymethyl chitosan solution with density at 1-4% and dialdehyde starch solution with density at 1-6% according to the weight rate at 1:0.5-5.0; stirring evenly under 30-60 Deg C; defoaming in the vacuum; stewing at indoor temperature for 6-36h to form gel; washing through deionized water; drying in the vacuum to obtain constant weight material as the product.

Description

technical field [0001] The invention belongs to the technical field of resources, medicine and chemical industry, and particularly relates to a preparation method of pH-sensitive dialdehyde starch cross-linked carboxymethyl chitosan hydrogel. Background technique [0002] pH-sensitive hydrogel means that the hydrogel will absorb water to swell or release water to shrink with the change of environmental pH value. The principle of pH sensitivity of this kind of hydrogel macromolecules is that there are acidic or basic groups (such as carboxyl and amino groups) in the self-network that can dissociate into ions. They can capture or release protons according to changes in the pH of the environment, resulting in different degrees of ionization, resulting in changes in the charge density and network structure of the gel network, and then swelling or contraction mutations (FloryP J.J Chemical Physics, 1977, 66: 5720; Zhang Kan, Zhang Liming. Guangzhou Chemistry, 2000, 26:46). The ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/08
Inventor 郑化岳智洲
Owner WUHAN UNIV OF TECH
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