Method and reagent for treatment of diseases caused by expression of the c-myc gene
Patent Information
- Authority / Receiving Office
- US · United States
- Patent Type
- Applications(United States)
- Current Assignee / Owner
- RIBOZYME PHARMA INC
- Publication Date
- 2004-02-19
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
[0001] This patent application is a continuation of Thompson, U.S. Ser. No. 08 / 192,943 filed Feb. 7, 1994, which is a continuation of Thompson, U.S. Ser. No. 07 / 936,422 filed Aug. 26, 1992, abandoned, all entitled "METHOD AND REAGENT FOR TREATMENT OF DISEASES CAUSED BY EXPRESSION OF THE c-MYC GENE". All of the above applications are hereby incorporated by reference herein in their entirety, including the drawings.BACKGROUND OF THE INVENTION
[0002] This invention relates to methods for inhibition of growth of transformed cells, and inhibition of progression to a transformed phenotype in pre-neoplastic cells.
[0003] Transformation is a cumulative process whereby normal control of cell growth and differentiation is interrupted, usually through the accumulation of mutations affecting the expression of genes that regulate cell growth and differentiation.
[0004] Scanlon W091 / 18625, W091 / 18624, and W091 / 18913 describes a ribozyme effective to cleave oncogene RNA from the H-ras gene. This ribo...