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Method for anion-exchange adsorption and anion-exchangers

a technology of anion exchange and anion exchange, which is applied in the field of anion exchange adsorption and anion exchange, can solve the problems that none of the methodologies in these three articles describe successful desorption processes, and achieve the effects of increasing ph, reducing ionic strength, and increasing binding to the ion exchange matrix

Inactive Publication Date: 2004-04-29
GE HEALTHCARE BIO SCI CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This approach enhances breakthrough capacities, recovery rates, and resistance to alkaline / acidic regeneration, enabling simplified desalting and cost-effective large-scale processes with improved productivity.

Problems solved by technology

None of the methodologies in these three articles describe successful desorption processes under anion-exchange conditions.

Method used

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  • Method for anion-exchange adsorption and anion-exchangers
  • Method for anion-exchange adsorption and anion-exchangers
  • Method for anion-exchange adsorption and anion-exchangers

Examples

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Embodiment Construction

[0218] Part I: Synthesis of Anion-Exchangerrs

[0219] General:

[0220] Volumes of matrix refer to sedimented bed volume. Weights of matrix given in gram refer to the suction dried weight. It is understood that these matrices are still water solvated material. For reactions on a large scale, stirring refers to the use of a suspended, motor-driven stirrer since the use of a magnet bar stirrer will to damage the beads. Small-scale reactions (up to 20 ml) were performed in closed vials on a shaking-table. Determination of the functionality and the extent of allylation, epoxidation, or the degree of substitution of ion exchanger groups on the beads were made using conventional methods. Elementary analyses of the gels were also performed especially for analysing of the sulphur content.

[0221] A typical example for preparing the anion-exchangerrs described above is exemplified below using Sepharose 6 Fast Flow (Amersham Pharmacia Biotech, Uppsala, Sweden) as the base matrix.

[0222] 1. Introducti...

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PUM

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Abstract

A method for the removal of a substance carrying a negative charge and being present in an aqueous liquid (I). The method comprises the steps of: (i) contacting the liquid with a matrix carrying a plurality of ligands comprising a positively charged structure and a hydrophobic structure, and (ii) desorbing the substance. The characterizing feature is that (I) each of said ligands together with a spacer has the formula: --SP---[Ar-R1-N<+>(R2R3R4)] where (A) [Ar-R1-N<+>(R2R3R4)] represents a ligand a) Ar is an aromatic ring, b) R1 is [(L)nR'1]m where n and m are integers selected amongst zero or 1; L is amino nitrogen, ether oxygen or thioether sulphur; R'1 is a linker selected among 1) hydrocarbon groups; 2) -C(=NH)-; c) R2-4 are selected among hydrogen and alkyls; (B) SP is a spacer providing a carbon or a heteroatom directly attached to Ar-R1-N<+>(R2R3R4); (C)--- represents that SP replaces a hydrogen in (Ar-R1-N<+>(R2R3R4); (D)-- represents binding to the matrix; and (II) desorption. There is also described (a) anion-exchangerrs having high breakthrough capacities, (b) a screening method and (c) a desalting protocol.

Description

[0001] The present invention relates a method for the removal of a compound (=substance) carrying a negative charge from an aqueous liquid (I). The method comprises the steps of[0002] i) contacting the liquid with an anion-exchanger that comprises a base matrix carrying a plurality of mixed mode anion-exchange ligands comprising (a) a positively charged structure and (b) a hydrophobic structure under conditions permitting binding between the ligands and the substance, and[0003] ii) desorbing said substance from said matrix by the use of a liquid (II).[0004] The invention also relates to novel anion-exchangers in which there are anion-exchange ligands comprising both a hydrophobic structure and a positively charged structure.[0005] The terms "carrying a negative charge" and "negatively charged" mean that the substance carries one or more negative charges and / or has a negative net charge.[0006] The terms "mixed mode anion-exchanger ligand" and "bimodal anion-exchanger ligand", in the ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): B01D15/32B01J20/281B01J20/34B01J41/04B01J41/08B01J41/12B01J41/20B01J49/00C02F1/28C02F1/42C07K1/18
CPCB01D15/327C02F1/42B01J41/20B01J41/085B01J41/09
Inventor JOHANSSON, BO-LENNARTANDERSSON, MIKAELGUSTAVSSON, JANBELEW, MAKONNENMALOISEL, JEAN-LUC
Owner GE HEALTHCARE BIO SCI CORP
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