Phase-separated polymer coatings

a phase separation and polymer coating technology, applied in the direction of powder delivery, medical preparations, microcapsules, etc., can solve the problems of difficult to prevent a rapid, uncontrolled release of drugs, and the troublesome burst effect, and achieve the effect of decreasing the rate of drug releas

Inactive Publication Date: 2005-05-12
CLAUDE CHARLES DAVID
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0014] One embodiment of the present invention includes a drug release system. The drug release system releases one or more drugs when implanted in a human being or other vertebrate but does not display a substantial release of drugs when outside of the human being or other vertebrates. The drug release system comprises a bulk polymer phase and a polymeric drug-enriched phase within the bulk polymer phase. The drug release system also includes at least one drug that is incorporated in the polymeric drug-enriched phase. The drug release system of the present invention releases one or more drugs in situ while decreasing the rate of release of the drug when the device is not in situ. The drug profile release is predictable and preselectable.

Problems solved by technology

One problem with sustaining drug release is that when drugs, particularly water soluble drugs, are incorporated into polymers, it is difficult to prevent a rapid, uncontrolled release of the drugs.
This rapid, uncontrolled release from a drug-polymeric matrix is known as a “burst effect.” The burst effect is particularly troublesome with high drug loading.

Method used

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Examples

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example 1

[0037] One exemplary composition that produces the drug release morphology of FIG. 3c includes an EVAL polymer with 66 weight percent ethylene groups, 43.32 weight percent vinyl alcohol functionalities and 0.68 weight percent vinyl ether groups. The weight percent refers to the percent of the total drug release system weight. The vinyl ether groups were functionalized with PEO-isocyanate, which forms a urethane linkage, using groups that have a molecular weight of a side group of 3200 g / mol. The side groups comprise 33 weight percent of the total EVAL / PEO polymer. The composition of the PEO-isocyanate blend is 75 weight percent functionalized EVAL and 25 weight percent drug. This composition gives rise to a 50 weight percent hard, bulk phase and a 50 weight percent drug / PEO side chain phase. The final structure is a lamellar structure.

[0038] The chemical reaction is as follows:

[0039] (x)=66 weight %; (y)=44 weight %. M is approximately equal to 70 units. Molecular weight is appro...

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Abstract

The present invention includes a drug release system. The drug release system comprises a bulk polymer phase and a polymeric drug-enriched phase within the bulk polymer phase. At least one, drug is incorporated into the drug-enriched phase.

Description

BACKGROUND OF THE INVENTION [0001] The present invention relates to a system for controlled drug release within a vessel lumen, and to a method and to a device for controlled drug release. [0002] A device for providing a continuous release of drugs over an extended period of time following from a single administration of a drug releasing material has wide application in treating disease. One type of continuous drug release mechanism is based upon degradation of biodegradable polymers. The biodegradable polymers have drugs incorporated within them. As the biodegradable polymers hydrolyze over time, the drugs are released. Hydroxycarboxylic acid polymers have been used to release drugs in this manner. [0003] One other modality of drug release is a prolonged, though discontinuous release of drugs. Frequently, with a discontinuous release, there is a lag phase of no or negligible drug release when a drug delivery device is delivered to an in situ site for drug release. [0004] One proble...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/00
CPCA61K9/0024
Inventor CLAUDE, CHARLES DAVID
Owner CLAUDE CHARLES DAVID
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