Automated molecular pathology apparatus having fixed slide platforms

Inactive Publication Date: 2007-04-19
VENTANA MEDICAL SYST INC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

ISH analysis, which relies upon the specific binding affinity of DNA or RNA probes with unique or repetitive nucleotide sequences from the cells of tissue samples or bodily fluids, requires a similar series of process steps with many different reagents and is further complicated by varying temperature requirements.
The problem with this method is that incubation times will not be accurate if the instrument is busy performing a task on one slide when it is time to be washing another slide (thereby completing incubation on that slide).
The variation in incubation times will be unpredictable since the total number of slides and the slide protocols vary.
While such convection or radiant heating systems have been generally suitable for IHC

Method used

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  • Automated molecular pathology apparatus having fixed slide platforms
  • Automated molecular pathology apparatus having fixed slide platforms
  • Automated molecular pathology apparatus having fixed slide platforms

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Embodiment Construction

[0038] Referring now in detail to the drawings wherein like parts are designated by like reference numerals throughout, there is illustrated in FIG. 1 a perspective view of the molecular pathology apparatus according to a first embodiment of the present invention which is designated generally by reference numeral 10. For the purposes of clarity, several of the reagent bottles, as well as the cabinet shell, and liquid and air supply tubing and electrical wiring are omitted from the drawings. Apparatus 10 is designed to automatically stain or otherwise treat tissue mounted on microscope slides with nucleic acid probes, antibodies, and / or other reagents in a desired sequence, time and temperature. Tissue sections so stained or treated are then to be viewed under a microscope by a medical practitioner who reads the slide for purposes of patient diagnosis, prognosis, or treatment selection.

[0039] In the first embodiment, apparatus 10 functions as one component or module of a system 12 (...

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Abstract

Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent, wash and coverslipping solutions brought to the slides. Alternatively, the slides are held in fixed position, while the reagent, wash and coverslipping solutions brought to the slides.

Description

CROSS REFERENCE TO RELATED APPLICATION [0001] This Application claims benefit of priority from U.S. Provisional Application Ser. No. 60 / 375,679 filed Apr. 26, 2002.FIELD OF THE INVENTION [0002] The present invention is directed to apparatus for use in diagnostic molecular pathology and, more particularly, to such apparatus used for the automated staining and / or treating of tissue samples mounted on microscope slides. BACKGROUND OF THE INVENTION [0003] Molecular pathology is the examination at a molecular level of the DNA, mRNA, and proteins that cause or are otherwise associated with disease. From this examination important information about patient diagnosis, prognosis, and treatment options can be elucidated. The practice of molecular pathology is generally divided into two main areas: (i) analysis of DNA, mRNA, and proteins in intact cells (in-situ), and (ii) analysis of these biological materials after they have been extracted from tissues. The first category, to which the prese...

Claims

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Application Information

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IPC IPC(8): G01N33/00G01N1/30G01N1/28G01N1/31G01N35/00
CPCG01N1/312Y10T436/115831Y10T436/111666Y10T436/11Y10T436/112499Y10T436/2575
Inventor LEMME, CHARLESCAMPBELL, DEVONGHUSSON, ANDREWBRYANT, DAVIDREINHARDT, KURTRICHARDS, WILLIAMRIZZO, VINCENTSHOWALTER, WAYNE
Owner VENTANA MEDICAL SYST INC
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