Radiographic contrasting agents and radio-opaque polymeric materials for medical devices

Inactive Publication Date: 2007-06-14
CORDIS CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, a fractured bone that has been fixated with a rigid metal implant has a tendency for refracture upon removal of the metal implant because the stress is borne by the rigid metal, so the bone has not been able to carry sufficient load during the healing process.
However, most biodegradable polymers are not radio-opaque.
Consequently, medical devices made from those biodegradable polymers cannot be visualized by means of radiographic imaging.
However, these inorganic agents do not mix well with polymeric materials and

Method used

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  • Radiographic contrasting agents and radio-opaque polymeric materials for medical devices
  • Radiographic contrasting agents and radio-opaque polymeric materials for medical devices
  • Radiographic contrasting agents and radio-opaque polymeric materials for medical devices

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Embodiment Construction

[0013] The present invention provides a radiographic contrasting agent comprising a monosaccharide backbone or an aliphatic or alicyclic backbone of 2 to 12 carbon atoms, a reactive nucleophilic group, and at least two halogen-substituted aromatic groups. By “monosaccharide”, it is meant a simple sugar that cannot be hydrolyzed to smaller units. Empirical formula for monosaccharide is (CH2O)n, wherein n is an integer of 1 to 9. As used herein, “an aliphatic backbone” denotes an organic moiety consisting of carbon atoms linked in open chains, and “an alicyclic backbone” denotes an organic moiety consisting of carbon atoms forming one or more rings that are not aromatic. The aliphatic or alicyclic backbone of the present invention contains 2 to 12 carbon atoms. By “a reactive nucleophilic group”, it is meant a reactive chemical moiety having an affinity to atomic nuclei. Reactive nucleophilic groups suitable for the present invention include, but are not limited to: NRH, OH, and SH; w...

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Abstract

The present invention discloses a radiographic contrasting agent containing multiple aromatic groups, each of which is substituted with at least three halogen atoms. The radiographic contrasting agent can initiate a polymerization process. The present invention also discloses a radio-opaque polymeric material that comprises a biodegradable polymer having at least one radiographic contrasting moiety covalently attached thereto. The radio-opaque polymeric material provides enhanced contrasting intensity in radiographic imaging. The radio-opaque polymeric material can be applied on at least a portion of one surface of a medical device. The radio-opaque polymeric material can also be used to construct a medical device, a component thereof, or a portion of a component thereof.

Description

FIELD OF INVENTION [0001] The present invention relates to a radiographic contrasting agent that can initiate a polymerization process and a radio-opaque polymeric material comprising a biodegradable polymer having at least one radiographic contrasting moiety covalently attached thereto. BACKGROUND OF INVENTION [0002] Biodegradable polymers have been widely used to construct medical devices, particularly implantable medical devices. Compared to the conventional metallic material, biodegradable polymers offer many advantages. First, biodegradable polymers are conformable and flexible, thereby causing less stress to the biological tissues. Second, medical implants made from biodegradable polymers do not require a second surgical intervention for removal. Third, the biodegradable polymers may be used to enhance the therapeutic effect of a medical implant. For example, a fractured bone that has been fixated with a rigid metal implant has a tendency for refracture upon removal of the met...

Claims

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Application Information

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IPC IPC(8): A61K49/04C07D229/02
CPCA61K49/0438A61K49/0442A61L17/06A61L17/145A61L27/34A61L27/58A61L31/10A61L31/148A61L31/18C07H13/08C07H17/02
Inventor ZHAO, JONATHON Z.
Owner CORDIS CORP
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