Process for the preparation of tiotropium bromide
Patent Information
- Authority / Receiving Office
- US · United States
- Current Assignee / Owner
- SICOR SOC ITAL CORTICOSTEROIDI SPA
- Publication Date
- 2008-02-28
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application claims the benefit of the filing date of U.S. Provisional Patent Application No. 60 / 830,231 filed Jul. 10, 2006; U.S. Provisional Patent Application No. 60 / 835,201, filed Aug. 3, 2006; U.S. Provisional Application No. 60 / 835,200, filed Aug. 3, 2006; and U.S. Provisional Application No. 60 / 836,037, filed Aug. 7, 2006, the disclosures of which are hereby incorporated herein by reference. This application is also related to U.S. patent application Ser. No. 11 / 643,013, filed Dec. 19, 2006.FIELD OF THE INVENTION
[0002] The invention is directed to improved processes for preparing Tiotropium bromide. BACKGROUND
[0003] Tiotropium bromide, (1α,2β,4β,5α,7β)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane bromide or 6β,7β-epoxy-3β-hydroxy-8-methyl-1αH,5αH-tropanium bromide, di-2-thienylglycolate, has the following chemical structure: It is an anticholinergic drug with specificity for muscar...