Composition and method for enhancing or promoting the activity of insulin, enhancing skeletal muscle growth, reducing skeletal muscle loss, and increasing the energy supply to skeletal muscle

Abstract

A dietary supplement and method for enhancing or promoting the activity of insulin, enhancing skeletal muscle growth, reducing skeletal muscle loss, and increasing the energy supply to skeletal muscle of an individual comprising at least D-Pinitol and Leucine or derivatives thereof. The dietary supplement may further comprise at least one of Alpha Lipoic Acid, Glucomannan, D-Myo-lnositol, Guar Gum, Taurine or derivative thereof, a derivative of Ketoisocaproic Acid, a derivative of Alpha-Ketoglutarate, and a source of Peptide C12.

Description

FIELD OF THE INVENTION[0001]The present invention relates to the composition of a dietary supplement and methods for enhancing or promoting the activity of insulin, enhancing skeletal muscle growth, reducing skeletal muscle loss, and increasing the energy supply to skeletal muscle.BACKGROUND OF THE INVENTION[0002]The most common role associated with insulin is the carbohydrate-induced uptake of glucose by cells. The release of glucose from cells is also concomitantly inhibited by insulin and its storage as glycogen and triglycerides is promoted (Khan A H, Pessin J E. Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways. Diabetologia. 2002 November;45(1 ):1475-83). However, insulin also has an important role with respect to the inhibition of muscle protein catabolism, or inhibition of protein breakdown, (Volpi E and Wolfe B. Insulin and Protein Metabolism. In: Handbook of Physiology, L. Jefferson and A. Cherrington editors. New York: Oxford, ...

AI Technical Summary

Benefits of technology

[0007]The present invention also provides, by consumption of the dietary supplement by an individual, e.g., a human or an animal, a method for enhancing or promoting the activity of insulin, enhancing skeletal muscle growth, reducing skeletal muscle loss, and increasing the energy supply to skeletal muscle.

Problems solved by technology

Second, insulin has been shown to interfere with and downregulate the ATP-dependent ubiquitin (Ub) pathway (Price S R, Bailey J L, Wang X, Jurkovitz C, England B K, Ding X, Phillips L S, Mitch W E. Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription.

Third, insulin reduces the expression of MAFbx, a muscle-specific Ub-ligase required for muscle atrophy.

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