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Tumor-targeted drug delivery systems and uses thereof

a drug delivery and tumor technology, applied in the direction of biocide, plant growth regulators, pharmaceutical non-active ingredients, etc., can solve the problems of non-target cell interaction, premature or inappropriate release of drugs, and limited clinical utility of liposomes in targeting drug delivery, so as to improve tumor vasculature permeability, improve tumor treatment, and increase localization

Inactive Publication Date: 2009-04-09
G GASLINI CHILDRENS HOSPITAL +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The system achieves increased drug delivery to tumors, with exposure levels 0.5-40 folds higher than conventional systems, reducing toxicity to normal tissues and improving therapeutic efficacy.

Problems solved by technology

As such, one of the challenges in treating cancerous tumors with chemotherapy is maximizing the killing of cancer cells while minimizing the harming of healthy tissue.
The antibody provides selectivity for the target, but there still remains the problem of interaction with non-target cells during passage to the intended site of action.
However, the clinical utility of liposomes in targeting drug delivery has been severely limited by: (1) the rapid clearance by phagocytic cells of the reticuloendothelial system (RES), (2) the lack of specific tumor targeting, and (3) the premature or inappropriate release of the drug.

Method used

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  • Tumor-targeted drug delivery systems and uses thereof
  • Tumor-targeted drug delivery systems and uses thereof
  • Tumor-targeted drug delivery systems and uses thereof

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Embodiment Construction

[0042]The invention relates to a novel approach for cancer treatment and prevention. Specifically, the invention relates to a tumor-targeted drug delivery system that delivers a therapeutic agent to tumor cells or tumor-supporting cells. The targeted drug delivery system selectively inhibits or destroys the endothelial cells of the tumor vasculature (using angiolytic, anti-angiogenic or anti-vascular drugs, respectively) and therefore, triggers tumor growth inhibition, regression and / or a state of dormancy. A strategy that targets both the tumor-supporting cells (e.g., tumor vasculature cells) and the tumor cells themselves may be more effective than strategies that target only the tumor vasculature cells, since this latter strategy can leave a cuff of unaffected tumor cells at the tumor periphery that can subsequently re-grow and kill the animals (Huang, et al. Science 275, 547-50 (1997)).

[0043]As such, the inventors have designed a drug delivery system that delivers an increased a...

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Abstract

The present invention relates to targeted delivery systems for delivering therapeutic agents to tumor. The invention further relates to methods of delivering a therapeutic agent to a tumor for the prevention and treatment of cancer by killing tumor cells and tumor-associated endothelial cells. In particular, the present invention provides a tumor-targeted drug delivery system comprising a NGR-containing molecule linked to a delivery vehicle encapsulating a therapeutic agent, preferably a drug, such as a cytotoxic agent or a chemotherapeutic agent. Specifically, the delivery systems of the present invention are capable of delivering an increased amount of therapeutic agent to a tumor as compared to other delivery systems. In particular, the delivery systems of the present invention are capable of accumulating a higher amount of therapeutic agent in a tumor, or in the vicinity of a tumor cell or tumor-supporting cell, resulting in exposure of the tumor cell and tumor-associated endothelial cell to therapeutic levels of the agent for a longer period of time as compared to other delivery systems. The present invention also describes pharmaceutical compositions comprising the delivery systems of the present invention. The present invention further relates to a tumor treatment comprising an increased amount of therapeutic agent delivered by the system of the present invention as compared to other delivery systems. The delivery systems and pharmaceutical compositions can be administered to a subject, preferably a human, alone or in combination, sequentially or simultaneously, with other prophylactic or therapeutic agents and / or anti-cancer treatments.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. patent application Ser. No. 10 / 853,895, filed May 26, 2004, which claims the benefit of United Kingdom Patent Application No. 0312309.8, filed May 29, 2003, herein incorporated by reference.1. FIELD OF THE INVENTION[0002]The present invention relates to targeted delivery systems for delivering therapeutic agents to tumors, in particular to tumor cells and tumor-associated endothelial cells. The invention further relates to methods of delivering a therapeutic agent to tumor cells and tumor-associated endothelial cells for the prevention and treatment of cancer by killing tumor cells and tumor-associated endothelial cells. In particular, the present invention provides a tumor-targeted drug delivery system comprising a NGR-containing molecule linked to a delivery vehicle encapsulating a therapeutic agent, preferably a drug, such as a cytotoxic agent or a chemotherapeutic agent. Specifically, the del...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K47/42A61K31/704A61K31/44A61K31/437A61K31/135A61K31/5377A61K31/496A61K31/7088A61K9/127A61K9/14A61K35/00A61K35/76A61K31/00A61K38/08A61K38/10
CPCA61K31/704A61K9/127A61K38/10A61K38/08A61K31/00A61P35/00
Inventor PONZONI, MIRCOCORTI, ANGELOALLEN, THERESA M.
Owner G GASLINI CHILDRENS HOSPITAL
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