Nitrogenatd trans-stilbene analogs, method for the obtention and medical applications thereof

a technology of transstilbene and nitrogenatd, which is applied in the preparation of isocyanic acid derivatives, drug compositions, biocides, etc., can solve the problem of not being able to achieve the usual high yield of this method
US20090298905A1Inactive Publication Date: 2009-12-03DOMINION PHARMAKINE +1
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
DOMINION PHARMAKINE
Publication Date
2009-12-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention is related to new nitrogenated trans-stilbene analog compounds, more specifically, imine, pyrrol and Indole derivatives, with procedures for the preparation and use thereof as pharmaceutical compositions for the treatment and / or chemoprevention of those mammalian diseases such as cancer, fibrosclerosis and acute / chronic inflammation, graft-versus-host reaction, ischemic-reperfusion tissue injury in stroke and heart attack, neurodegeneration, and during organ transplantation, whose pathogenic and pathophysiological mechanisms depend on or are significantly contributed by undesirable oxidative stress, angiogenic and proliferative responses.
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Description

[0001] This invention is related to new nitrogenated trans-stilbene analog compounds, more specifically, imine, pyrrol and indole derivatives, with procedures for the preparation and use thereof as pharmaceutical compositions for the treatment and / or chemoprevention of those mammalian diseases such as cancer, fibrosclerosis and acute / chronic inflammation, graft-versus-host reaction, ischemic-reperfusion tissue injury in stroke and heart attack, neurodegeneration, and during organ transplantation, whose pathogenic and pathophysiological mechanisms depend on or are significantly contributed by undesirable oxidative stress, angiogenic and proliferative responses.BACKGROUND OF THE INVENTION

[0002] It is known that the chemical synthesis of aromatic imines (or Schiff bases) can generally be achieved by means of the condensation between primary amines and carbonylic compounds (cf. Patai, The Chemistry of Carbon-Nitrogen Double Bond; Wiley: New York, 1970, pp. 64).

[0003] Likewise, polysubstitu...

Claims

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