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Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles

a technology of optical forces and characterization, applied in the field of methods and apparatus for using optical forces for identification, characterization and/or sorting of particles, can solve the problems that existing technologies cannot efficiently and comprehensively address the enormous complexity of this information, and achieve the effect of reducing the contamination to the system

Inactive Publication Date: 2010-05-06
CELULA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

This patent describes a method and system for using light to analyze and interact with particles, such as cells, without labeling or modifying them. The system uses optical forces to create an interaction with the particles, which results in a unique signature that can be used to identify and characterize the particles. The system can also sort and isolate specific particles for further analysis and treatment. The technique is applicable in both the biological and non-biological realms, and can be used to study the inner workings of cells and monitor their activity. Overall, the patent provides a way to unlock the inner workings of particles and improve the efficiency of analyzing and manipulating them.

Problems solved by technology

Existing technologies cannot efficiently and comprehensively address the enormous complexity of this information.

Method used

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  • Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
  • Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
  • Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles

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Definitions

[0075]The following definitions are provided for an understanding of the invention disclosed herein.

[0076]“Dielectric constant” is defined to be that property which determines the electrostatic energy stored per unit volume for unit potential gradient. (See, e.g., the New IEEE Standard Dictionary Of Electrical And Electronics Terms, ©1993).

[0077]The “optical dielectric constant” is the dielectric constant of a particle or thing at optical wavelengths. Generally, the optical wavelength range is from 150 Å to 30,000 Å.

[0078]An “optical gradient field” is an optical pattern having a variation in one or more parameters including intensity, wavelength or frequency, phase, polarization or other parameters relating to the optical energy. When generated by an interferometer, an optical gradient field or pattern may also be called an optical fringe field or fringe pattern, or variants thereof.

[0079]A “moving optical gradient field” is an optical gradient field that moves in space ...

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Abstract

Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells, in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly moving optical gradient forces, so as to obtain useful results. In biology, this technology represents a practical approach to probing the inner workings of a living cell, preferably without any dyes, labels or other markers. In one aspect, a particle may be characterized by determining its optophoretic constant or signature. For example, a diseased cell has a different optophoretic constant from a healthy cell, thereby providing information, or the basis for sorting. In the event of physical sorting, various forces may be used for separation, including fluidic forces, such as through the use of laminar flow, or optical forces, or mechanical forces, such as through adhesion. Various techniques for measuring the dielectric constant of particles are provided.

Description

RELATED APPLICATIONS[0001]This application is a Continuation of U.S. application Ser. No. 11 / 272,593, filed Nov. 11, 2005; which is a Continuation of U.S. application Ser. No. 09 / 845,245, filed Apr. 27, 2001, and is related to U.S. application Ser. No. 09 / 843,902, filed Apr. 27, 2001, which claims priority from provisional Application Ser. No. 60 / 248,451, filed Nov. 13, 2000, the contents of which are incorporated by reference herein in its entirety as if fully set forth herein.FIELD OF THE INVENTION[0002]This invention relates to methods and apparatus for the selection, identification, characterization, and / or sorting of materials utilizing at least optical or photonic forces. More particularly, the inventions find utility in biological systems, generally considered to be the use of optical forces for interaction with bioparticles having an optical dielectric constant.BACKGROUND OF THE INVENTION[0003]Separation and characterization of particles has a wide variety of applications ra...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): B07C5/36B07C5/34G01N15/00C12Q1/04G01N15/14G01N30/02G21K1/00
CPCB07C5/34G01N15/1459G01N15/1463G01N30/02G01N2015/1486G01N2015/149H05H3/04B01D2015/3895G01N15/1433G01N15/149
Inventor WANG, MARK M.TU, EUGENEPESTANA, LUIS M.SENYEI, ANDREW E.O'CONNELL, JAMES P.NOVA, TINA S.LYKSTAD, KRISTIE L.HALL, JEFFREY M.BUTLER, WILLIAM F.
Owner CELULA
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