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Skin substitute membrane, mold, and method of evaluating external preparation for skin

Inactive Publication Date: 2011-04-28
SHISEIDO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0025]According to the present invention, it is possible to provide a skin substitute membrane that makes it possible to measure the ultraviolet radiation transmission characteristic and / or reflection characteristic of an external preparation for skin with accuracy, a mold used for manufacturing the skin substitute membrane, and a method of evaluating an external preparation for skin using the skin substitute membrane.

Problems solved by technology

However, measuring the in vivo SPF necessitates the cooperation of a large number of volunteers of specific skin types, thus requiring a large amount of money and a large number of days.
However, no known skin substitute membrane allows an external preparation for skin to be evenly applied with such an amount of application.

Method used

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  • Skin substitute membrane, mold, and method of evaluating external preparation for skin
  • Skin substitute membrane, mold, and method of evaluating external preparation for skin
  • Skin substitute membrane, mold, and method of evaluating external preparation for skin

Examples

Experimental program
Comparison scheme
Effect test

first embodiment

[0047]A skin substitute membrane of this embodiment has a surface with an arithmetic mean roughness Sa of 13 μm to 30 μm, preferably 15 μm to 25 μm. Further, the skin substitute membrane of this embodiment has a spectral transmittance of 50% to 100%, more preferably 60% to 100%, for light of 290 nm to 400 nm in wavelength. As a result, a skin substitute membrane is obtained that makes it possible to measure the ultraviolet radiation transmission characteristic and / or reflection characteristic of an external preparation for skin with accuracy. Such a skin substitute membrane allows reproduction of the amount of application of an external preparation for skin in measuring in vivo SPFs determined in Non-Patent Document 3, which is 2.00 mg / cm2, and is therefore particularly effective in evaluating the estimated in vitro SPFs of an external preparation for skin subject to degradation due to ultraviolet radiation.

[0048]At this point, if the arithmetic mean roughness Sa of the surface of t...

second embodiment

[0063]The surface of one side of a skin substitute membrane of this embodiment includes groove-shaped depressed portions whose cross sections have a chamfered V-letter shape and planar portions, and has an arithmetic mean roughness Sa of 10 μm to 50 μm, preferably 10 μm to 30 μm. Further, the depressed portions are 50 μm to 500 μm, preferably 200 μm to 400 μm, in width. Further, the depressed portions are 30 μm to 150 μm, preferably 50 μm to 100 μm, in depth. Further, the skin substitute membrane of this embodiment has a spectral transmittance of 50% to 100%, more preferably 60% to 100%, for light of 290 nm to 400 nm in wavelength. As a result, a skin substitute membrane is obtained that makes it possible to measure the ultraviolet radiation transmission characteristic and / or reflection characteristic of an external preparation for skin with accuracy. Such a skin substitute membrane allows reproduction of the amount of application of an external preparation for skin in measuring in ...

third embodiment

[0084]A method of evaluating an external preparation for skin of this embodiment includes the process of applying the external preparation for skin on the skin substitute membrane of the first embodiment or the second embodiment of the present invention and the process of evaluating the ultraviolet radiation transmission characteristic and / or reflection characteristic of the external preparation for skin by exposing the skin substitute membrane on which the external preparation for skin is applied to light containing ultraviolet radiation.

[0085]Here, the amount of application of the external preparation for skin is preferably 1.20 mg / cm2 to 2.40 mg / cm2. This makes it possible to measure the ultraviolet radiation transmission characteristic and / or reflection characteristic of the external preparation for skin with accuracy.

[0086]External preparations for skin are not limited in particular, and include sunscreen cosmetics, makeup cosmetics, skin-care cosmetics, pre-makeup cosmetics, a...

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Abstract

A skin substitute membrane includes a surface on one side including a groove-shaped depressed portion and a planar portion, the depressed portion having a cross section having a chamfered V-letter shape, the surface having an arithmetic mean roughness Sa of more than or equal to 10 μm to less than or equal to 50 μm. The depressed portion has a width of more than or equal to 50 μm to less than or equal to 500 μm and a depth of more than or equal to 30 μm to less than or equal to 150 μm. A spectral transmittance for light of more than or equal to 290 nm to less than or equal to 400 nm in wavelength is more than or equal to 50% and less than or equal to 100%.

Description

TECHNICAL FIELD[0001]The present invention relates to a skin substitute membrane, a mold, and a method of evaluating an external preparation for skin.BACKGROUND ART[0002]Conventionally, the in vivo SPF is used as a scale representing the ultraviolet radiation protection effect of external preparations for skin for preventing sunburn due to ultraviolet radiation, such as sun protection products. This SPF, which is an index indicating the effect of skin protection from sunburn due to ultraviolet radiation and sunburn prevention, is defined by the value obtained by dividing the amount of ultraviolet radiation necessary for causing slight redness in the case of using an external preparation for skin by the amount of ultraviolet radiation necessary for causing slight redness in the case of not using an external preparation for skin. For example, sunburn is ten times less likely to be caused with use of a sun protection product of in vivo SPF 10 than in the case of bare skin.[0003]The in ...

Claims

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Application Information

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IPC IPC(8): A61F2/10
CPCG01N33/5082
Inventor MIURA, YOSHIMASAMIZUNO, HIROKOHATAO, MASATOOOGURI, MOTOKIHARA, YUSUKE
Owner SHISEIDO CO LTD